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Digitale Medien

Age-of-onset heterogeneity in hereditary breast cancer: Minimal clues for diagnosis (1988)

Lynch, Henry T. ; Conway, Theresa ; Fitzgibbons, Robert ; [weitere]

Springer

Breast cancer research and treatment 12 (1988), S. 275-285

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Details

ISSN: 1573-7217

Schlagwort(e): hereditary breast cancer ; early onset ; diagnostic clues ; family history

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integral tumor combinations in certain kindreds, and vertical transmission consonant with an autosomal dominantly inherited factor, when observed in context with the family history, enables pattern recognition so that the diagnosis might be facilitated. We describe seven families from our Hereditary Cancer Consultation Center (HCCC) and the Creighton Oncology Clinic which are noteworthy for extraordinarily early age of onset. This appears to be an additional example of heterogeneity in HBC and may represent the first account of this remarkable subset. The manner in which age of onset can be incorporated with other aspects of natural history for expediting diagnosis is discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01811240

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