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  • 1
    Digitale Medien
    Digitale Medien
    Separation of two βγ subunit complexes of brain GTP-binding proteins composed of distinct γ subunits
    Amsterdam : Elsevier
    FEBS Letters 266 (1990), S. 41-44 
    Details
    ISSN: 0014-5793
    Schlagwort(e): GTP-binding protein ; Phosphorylation ; Protein kinase C ; γ Subunit
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(90)81501-E
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    A brain-specific γ subunit of G protein freed from the corresponding β subunit under non-denaturing conditions
    Amsterdam : Elsevier
    FEBS Letters 337 (1994), S. 23-26 
    Details
    ISSN: 0014-5793
    Schlagwort(e): Bovine brain ; G protein ; βγ Complex ; γ Subunit
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80622-5
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  • 3
    Digitale Medien
    Digitale Medien
    Characterisation of the effect of intravenous infusion of glucose and tolbutamide on the insulin delivery rate in man (1978)
    Springer
    Diabetologia 15 (1978), S. 159-164 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin delivery rate ; insulin secretion in man ; glucose ; tolbutamide ; insulin disappearance rate ; biphasic insulin secretion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Serum insulin response to a single bolus of IV glucose or tolbutamide was measured in eight healthy subjects. Insulin disappearance rate was assessed by deconvolution from the serum insulin levels, using the measured insulin disappearance rate. The mean rate constant of insulin disappearance was 0.238±0.005 min−1 (mean±SEM). Basal insulin delivery rate was 8.0 to 9.0 mU/min and the delivery rate following glucose injection (0.5 g/kg body weight) showed a biphasic response, whereas that after tolbutamide injection (15.6 mg/kg body weight), a monophasic response. After glucose injection, 1.7±0.3 U of insulin was delivered during the first phase (0–10 min) and 5.6±1.6 U during the second phase (11–60 min). After tolbutamide injection, 1.5±0.3 U of insulin was delivered during the first 10 min. Between 11 and 40 min, 1.6±0.5 U of insulin was delivered. The results thus confirm and also quantitate biphasic insulin secretion after a bolus of glucose with a monophasic response after tolbutamide. The method is suitable for studies of the insulin secretogogues in man.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00421232
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  • 4
    Digitale Medien
    Digitale Medien
    Insulin delivery rate in response to glucose and arginine infusion in hyperthyroidism (1982)
    Springer
    Diabetologia 23 (1982), S. 108-113 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Insulin delivery rate ; insulin secretion in hyperthyroidism ; glucose ; arginine ; insulin disappearance rate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Insulin delivery rates were estimated from the peripheral serum insulin response to a single bolus injection of glucose or arginine in eight normal subjects and eight patients with hyperthyroidism. The mean rate constant for insulin disappearance was 0.2380±0.0052 per min in the control subjects, which was not significantly different from that observed in the patients with hyperthyroidism (0.2147±0.0111 per min). There were also no significant differences in the insulin response to glucose infusion (1.7±0.3 U during the first phase (0–10 min) and 5.6±1.6 U during the second phase (11–60 min) in normal subjects compared with 1.2±0.5 and 3.7±1.1 U respectively in the hyperthyroid patients). The delivered insulin in response to glucose infusion was similar in the two groups. The kg-value in the patients with hyperthyroidism was lower than that in the control subjects (1.24±0.11 versus 2.11±0.22;p 〈 0.005). In hyperthyroidism, the low kg-value was not a result of the diminished insulin delivery to the general circulation. Insulin delivery showed a monophasic pattern following arginine infusion in both patients and control subjects. For the control subjects, the amount of insulin delivered was estimated to be 0.53±0.12 U during the first 10 min and 0.37±0.14 U during 11–30 min. In hyperthyroidism, the amount of insulin delivered was significantly lower than in the control subjects (0.21±0.06 U during the first 10 min and 0.07±0.03 U during 11–30 min). In the control subjects, the plasma glucose level was raised transiently following arginine infusion, but in hyperthyroidism, there was no change in plasma glucose levels. In hyperthyroidism, therefore, glucose intolerance appears to be primarily related to an antagonism of the hepatic effect of insulin by thyroxine rather than an inhibitory effect of thyroxine on insulin secretion. However, since delivery rate represents the measurement of peripheral serum insulin concentrations, these results cannot exclude an abnormality of hepatic insulin metabolism in hyperthyroidism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01271170
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