ISSN:
1573-8221
Schlagwort(e):
interferon production
;
action of adrenalin and theophylline
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Investigation of the effect of adrenalin and theophylline on interferon synthesis induced in chick embryonic cells by influenza B virus (Lee strain) showed that the action of these substances on interferon production depended on the age of the cell culture. In a one-day culture adrenalin (0.2 μg/ml) did not affect interferon formation but theophylline (400 μg/ml) stimulated it considerably. In a five-day culture both substances in the same concentrations inhibited interferon synthesis; their action was potentiated if they were given together and it was manifested even if the substances were added 4 h after the beginning of infection of the cells. In the concentration used, the two substances separately or together did not affect proliferation of influenza B virus (Lee strain) in chick embryos, or likewise vesicular stomatitis, Newcastle disease, and Chikungunya viruses in the cells of chick embryos. They had no toxic action on the cells of the tissue culture. The results are discussed from the point of view of the possible effect of the intracellular cyclic AMP level on the synthesis of virus-induced interferon.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00786420
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