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  • 1
    Digitale Medien
    Digitale Medien
    Langerhans’cells in human cervical epithelium: effects of wart virus infection and intraepithelial neoplasia (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. The distribution of Langerhans’cells and T and B lymphocytes in cervical epithelium affected by wart virus infection (WVI) and intraepithelial neoplasia (CIN) has been studied by immunohistological techniques with a panel of monoclonal antibodies. In comparison with normal tissue epithelium infected by wart virus consistently showed a partial depletion or absence of both Langerhans’cells and T lymphocytes. The few Langerhans’cells which remained showed loss of their normal dendritic processes and were confined to the vicinity of the basement membrane. In contrast, epithelium from patients with CIN showed an increase in spindle-shaped Langerhans’cells associated with increased numbers of stromal and intraepithelial lymphoid cells. These findings suggest that there is a marked difference in host immune responses in these two conditions and may explain why WVI tends to persist in the epithelium while CIN is often associated with a lymphoid reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb08936.x
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  • 2
    Digitale Medien
    Digitale Medien
    Langerhans’cells in human cervical epithelium: an immunohistological study (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Langerhans’cells are intraepithelial dendritic cells believed to be important in the recognition and processing of exogenous antigens. They were demonstrated by immunohistological methods in cervical tissue obtained from 10 subjects ranging in age from 30 weeks gestational age to 62 years. Langerhans’cells were clearly delineated in all tissue sections and appear to form a relatively constant component of both the transformation zone and ectocervical epithelium. In addition to Langerhans’cells, a population of T lymphocytes characterized as predominantly T-cytotoxic/suppressor cells have also been demonstrated. The interaction between Langerhans’cells, T lymphocytes and stromal macrophages and their relation to antigen recognition is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb08935.x
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  • 3
    Digitale Medien
    Digitale Medien
    The expression of the CD3 antigen in Hodgkin's disease (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Tissue from 86 cases of Hodgkin's disease, fixed in formalin and embedded in paraffin, was immunostained for the T-cell marker CD3. Of these cases, 20 were selected on the basis of previous reactivity of Reed-Sternberg cells for T-cell associated antigens in frozen sections whilst the remaining 66 were retrieved from the routine pathology files. Five of the 20 selected cases and 22 of the retrieved cases showed predominantly cytoplasmic positivity in a subpopulation of Hodgkin and Reed-Sternberg cells. CD3 positive cells were present in all subtypes of Hodgkin's disease including three of nine lymphocyte predominance cases. It therefore appears that some Hodgkin and Reed-Sternberg cells can express the major T-cell antigen CD3. Although these findings are open to other interpretations, they are consistent with the hypothesis that at least some cases of Hodgkin's disease arise from activated T-cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb01625.x
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  • 4
    Digitale Medien
    Digitale Medien
    Which antibodies for diagnostic pathology? (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 11 (1987), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1987.tb02677.x
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  • 5
    Digitale Medien
    Digitale Medien
    Langerhans cells in human lung tumours: an immunohistological study (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In an immunocytochemical study of 41 human lung tumours we have shown that Langerhans cells can be reliably identified using the anti-CD1 monoclonal antibody NA1/34. Langerhans cells are present in all the main varieties of human lung tumour although they are infrequent in both small cell carcinoma and carcinoid tumour. There is considerable variation in numbers of Langerhans cells in both adenocarcinomas and squamous cell carcinomas. In this study tumours were divided into those with high numbers of Langerhans cells (〉 2 per high power field) and those with low numbers (〈 2 per high power field). Analysing these results against patient survival showed a markedly worse survival in those tumours with a high number of Langerhans cells for all the tumours as a single group and for squamous cell carcinoma as a single entity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb02145.x
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  • 6
    Digitale Medien
    Digitale Medien
    Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Aims : The cellular response to hypoxia includes the hypoxia inducible factor (HIF)-induced transcription of genes involved in diverse processes such as glycolysis, angiogenesis and the growth of experimental tumours. Regulation of the level of hypoxia inducible factors 1α and 2α (HIF-1α and HIF-2α) is a primary determinant of HIF activity. Recent biochemical and candidate gene approach studies have led to the discovery of three HIF-regulatory prolyl hydroxylases, PHD-1, -2 and -3 and an asparaginyl hydroxylase, also known as FIH (factor inhibiting HIF). In this study, we raised and characterized monoclonal antibodies against PHD-1, PHD-2, PHD-3 and FIH.Methods and results : Immunohistochemistry of normal tissues with these monoclonal antibodies demonstrated a wide distribution in epithelial cells, stromal cells and leucocytes, with cytoplasmic staining predominating over nuclear staining. A preliminary study of tumours showed variable staining in tumour, stromal and inflammatory cells. While all tumour types showed some positive staining with each antibody, the overall pattern suggested a slight decrease in the amount of staining seen with PHD-1, -2 and -3 and an increase in FIH staining in neoplasia compared with corresponding normal tissues.Conclusions : These monoclonal antibodies will allow further larger scale studies to determine the significance of PHD and FIH expression in neoplasia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02280.x
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  • 7
    Digitale Medien
    Digitale Medien
    Is it necessary to embed bone marrow biopsies in plastic for haematological diagnosis? (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 11 (1987), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: With the increase in the use of bone marrow trephines for diagnosis have come numerous reports that traditional methods of preparation (by decalcification and embedding in paraffin wax) should be replaced by plastic embedding to avoid decalcification. It has been argued that only by this means can the high quality preparations needed for accurate haematopathological diagnosis be achieved. The present study challenges this viewpoint and argues that with a little extra care and attention conventional paraffin embedding techniques can give equally high quality preparations. Sections prepared in this way meet the diagnostic needs of the haematologist, without requiring a separate technique to be established in the pathology laboratory solely for bone marrow trephines.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1987.tb02604.x
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  • 8
    Digitale Medien
    Digitale Medien
    The prognostic significance of immunophenotype in high-grade non-Hodgkin's lymphoma (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 14 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The prognostic value of immunophenotyping lymphomas was assessed by studying 51 cases of high-grade non-Hodgkin's lymphoma for which long term clinical follow-up (14–28 years) was available. Using antibodies which identify T- and B-cell-related antigens in formalin-fixed, paraffin-embedded material, 43 were shown to be of B-cell and eight of T-cell phenotype. In terms of survival, cases of high-grade T-cell lymphoma fared significantly worse (P 〈 0.05) than cases of high-grade B-cell subtype. These findings support the belief that T-cell lymphomas have a more aggressive clinical course than their B-cell counterparts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb02203.x
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  • 9
    Digitale Medien
    Digitale Medien
    The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The production and characterization of a new monoclonal antibody, Y2/51, against platelet glycoprotein IIIa is described. A useful feature of this antibody is its ability to recognize platelets and megakaryocytes in formalin-fixed routinely processed material. It could also be used to reveal platelets both in thrombi in large vessels and in microthrombi too small to be readily apparent on conventional microscopic examination. For this purpose it was helpful to use the antibody in conjunction with a new monoclonal reagent (Ret40f) against red cell sialoglycoprotein β-which detects red cells and their precursors in routinely processed tissue. The use of these antibodies should be valuable for the detection of thrombi in a variety of situations such as renal transplant rejection, coronary artery disease and vasculitis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02037.x
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  • 10
    Digitale Medien
    Digitale Medien
    Correspondence (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb03091.x
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