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  • 1
    Electronic Resource
    Electronic Resource
    The intubating laryngeal maskClinical appraisal of ventilation and blind tracheal intubation in 110 patients (1998)
    Oxford : Blackwell Science Ltd
    Anaesthesia 53 (1998), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study assesses the efficacy of the intubating laryngeal mask as a ventilation device and blind intubation guide. Following induction of anaesthesia with propofol, the device was successfully inserted at the first attempt in 110/110 (100%) patients. Placement took less than 10 s in all patients. Size selection was based on nose–chin distance. Adequate ventilation was achieved in 104/110 (95%) patients. Blind tracheal intubation using an 8-mm internal diameter straight silicone cuffed tracheal tube was attempted 3 min after the administration of vecuronium. Passage of a lighted stylet through the intubating laryngeal mask was used to determine the position of the intubating laryngeal mask cuff before blind intubation. If resistance was felt during intubation, a sequence of adjusting manoeuvres was used, based on the depth at which resistance occurred. Tracheal intubation was possible in 104/104 (100%) patients. In 42 (40%) patients, no resistance was encountered and the trachea was intubated at the first attempt. Sixty-two (60%) patients required one adjusting manoeuvre. The mean (range) time taken to successful intubation, i.e. the time from disconnection of the intubating laryngeal mask from the breathing system to successful tracheal intubation, was 79 (12–315) s. Six patients with potential or known intubation problems were included in the study. The tracheas of all six patients were successfully intubated. We conclude that the intubating laryngeal mask is an effective ventilation device and intubation guide with potential for use in patients who may present difficulty in tracheal intubation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1998.00428.x
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  • 2
    Electronic Resource
    Electronic Resource
    Seismic deformation in the Mediterranean area estimated by moment tensor summation (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 122 (1995), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Theoretical relationships allow the distributed deformation due to seismic activity to be quantified on the basis of the analysis of moment tensors. We apply this method to a data set consisting of seismic events that have occurred in the past 85 yr (1908–1992) along the most important seismogenic zones of the Mediterranean region. We use the Centroid Moment Tensor (CMT) Catalog prepared at Harvard University, covering the last 16 yr, and older data from Jackson & McKenzie (1988). We determine the seismic deformation and compare it to estimates of the overall deformation as obtained from global plate motion and geological studies. We generally find that the geometry of seismic deformation is similar to tectonic predictions. Even though spanning a shorter time interval, the CMT Catalog often gives a better estimate of deformation geometry than the whole data set (85 yr). Seismic deformation generally ranges from less than 10 per cent to more than 90 per cent of the total deformation. Uncertainties arise because data sets may not be representative of the long-term seismic behaviour of each zone. More reliable estimates for comparison with geodynamic processes should result from analysis of a longer time period, for which no instrumental data are available. The similarity of the deformation geometry using CMT data with tectonic expectations suggests, for several zones, the possibility of using historical data to infer longer term deformation rates based on current deformation geometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1995.tb06847.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia (2002)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To investigate whether levosulpiride, a D2 antagonist, modulates gastric sensitivity and compliance in dyspeptic patients.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Eight healthy subjects and 16 dyspeptic patients underwent graded gastric distensions using a tensostat. In dyspeptic patients the same isotonic distensions were repeated during either levosulpiride or saline administration. Eight FD patients were evaluated after 4-week treatment with oral levosulpiride. Gastrointestinal symptoms were evaluated using a 100 mm visual analogue score. Perception was scored on a scale of 0 to 6.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Although healthy subjects and FD patients had similar gastric compliance, FD patients tolerated lower tension levels. At the same distending tension levels, levosulpiride decreased gastric compliance and perception score (14 ± 6% and 38 ± 10% change, respectively; P 〈 0.05 vs. saline) only in FD patients. Isotonic distensions exhibited very reproducible perception. Chronic levosulpiride administration significantly reduced dyspeptic symptoms and increased discomfort threshold.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Compared with healthy subjects, FD patients show marked gastric hypersensitivity. In FD patients levosulpiride decreased the perception of gastric distension with an action unrelated to change of gastric tone. Chronic levosulpiride administration significantly ameliorates gastrointestinal symptoms and increases the discomfort threshold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01180.x
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  • 4
    Electronic Resource
    Electronic Resource
    NSAIDs upregulate β2-integrin expression on human neutrophils through a calcium-dependent pathway (1997)
    Oxford UK : Blackwell Science Ltd.
    Alimentary pharmacology & therapeutics 11 (1997), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Margination of circulating neutrophils (PMN) into the gastric microcirculation is an early and critical event in the pathogenesis of non-steroidal antinflammatory drug (NSAID)-induced gastropathy. This effect is mediated through the upregulation of β2 integrins on the PMN surface.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:To investigate whether indomethacin modulates: (1) Mac-1 expression; (2) Ca2+ mobilization ([Ca2+]i), protein kinase C and nitric oxide accumulation; and (3) mitogen-associated protein kinase phosphorylation in human PMN.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Human PMN were isolated by centrifugation through a double Ficoll gradient. [Ca2+]i was measured in PMN loaded with fura-2 and Mac-1 expression by flow cytometry.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Indomethacin caused a concentration- and time-dependent upregulation of CD11b and CD18 expression and PMN adhesion to endothelial cells. Maximal upregulation of Mac-1 expression (40–50%) occurred after a 30-min incubation with 0.1 mM indomethacin. The effect was prevented by removing the Ca2+. Ionomycin and thapsigargin caused a 7–10-fold increase in [Ca2+]i and a 2–4-fold increase in Mac-1 expression. Indomethacin induced a concentration-dependent phosphorylation of a 41-kDa mitogen-associated protein kinase. Tyrosine kinase inhibitors prevented the effect of indomethacin on Mac-1 expression and Ca2+ mobilization. Indomethacin and ionomycin increased superoxide generation, myeloperoxidase secretion and PMN adherence to endothelial cells and stimulated nitric oxide production. Indomethacin-induced Mac-1 upregulation was prevented by a nitric oxide synthase inhibitor.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Indomethacin-induced upregulation of Mac-1 is mediated by changes in [Ca2+]i and nitric oxide. Phosphorylation of the 41-kDa mitogen-associated protein isoform is a previously unreported target of NSAID action. These effects might help to explain the ability of indomethacin to cause gastric neutrophil margination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1997.00190.x
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  • 5
    Electronic Resource
    Electronic Resource
    Decay of proteinase and peptidase activities of human and rabbit erythrocytes during cellular aging
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 675 (1981), S. 110-116 
    Details
    ISSN: 0304-4165
    Keywords: (Erythrocyte) ; Aging ; Peptidase ; Protein turnover ; Proteinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(81)90075-1
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  • 6
    Electronic Resource
    Electronic Resource
    Calcium ion-regulated phospholipase C activity in bovine rod outer segments
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 173 (1990), S. 283-288 
    Details
    ISSN: 0006-291X
    Keywords: [abr] BSA; bovine serum albumin ; [abr] DOC; Sodiumdeoxycholate ; [abr] IP"3; inositol 1,4,5-trisphosphate ; [abr] PC; phosphatidyl choline ; [abr] PI; phosphatidyl inositol ; [abr] PIP"2; phosphatidylinositol 4,5-bisphosphate ; [abr] PLC; phosphatidyl inositol-specific phosphodiesterase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(05)81054-X
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  • 7
    Electronic Resource
    Electronic Resource
    In vitro correction of erythrocyte glucose 6-phosphate dehydrogenase (G6PD) deficiency
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 197 (1979), S. 543-550 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(79)90278-9
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  • 8
    Electronic Resource
    Electronic Resource
    Oxidative inactivation of the calcium-stimulated neutral proteinase from human red blood cells by divicine and intracellular protection by reduced glutathione
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 251 (1986), S. 1-8 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(86)90044-5
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  • 9
    Electronic Resource
    Electronic Resource
    An improved procedure for rapid isolation or glucose 6-phosphate dehydrogenase from human erythrocytes
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 169 (1975), S. 362-363 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(75)90353-7
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  • 10
    Electronic Resource
    Electronic Resource
    Calcium ion-regulated phospholipase C activity in bovine rod outer segments
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 173 (1990), S. 283-288 
    Details
    ISSN: 0006-291X
    Keywords: [abr] BSA; bovine serum albumin ; [abr] DOC; Sodiumdeoxycholate ; [abr] IP"3; inositol 1,4,5-trisphosphate ; [abr] PC; phosphatidyl choline ; [abr] PI; phosphatidyl inositol ; [abr] PIP"2; phosphatidylinositol 4,5-bisphosphate ; [abr] PLC; phosphatidyl inositol-specific phosphodiesterase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(05)81054-X
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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