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  • 1
    Digitale Medien
    Digitale Medien
    Selective augmentations of intratumoral 5-fluorouracil concentration by local immunotherapy with OK-432 and fibrinogen (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 402-407 
    Details
    ISSN: 1530-0358
    Schlagwort(e): Colorectal carcinoma ; Chemoimmunotherapy ; OK-432 ; 5′-DFUR ; PyNPase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract PURPOSE: Pyrimidine nucleoside phosphorylase is an enzyme that converts 5′-deoxy-5-fluorouridine into its active metabolite, 5-fluorouracil. In colorectal cancer tissue pyrimidine nucleoside phosphorylase has been proven to be produced by macrophages in the cancer stroma despite presence of the cancer cells. We reported that local immunotherapy with OK-432 and fibrinogen induced aggregation of macrophages in the cancer stroma and enforced their pyrimidine nucleoside phosphorylase expression. Thus it was hypothesized that if colon cancer were treated with 5′-deoxy-5-fluorouridine, the 5-fluorouracil concentration in cancer tissues would be enhanced by local immunotherapy. The present study was conducted to investigate whether local immunotherapy for colon cancer could increase the intratumoral 5-fluorouracil concentration in patients given chemotherapy with 5′-deoxy-5-fluorouridine. METHODS: Twenty patients with resectable colorectal cancer were examined in this study. They were given 5′-deoxy-5-fluorouridine (600 mg/day) orally for seven days preoperatively. Nine randomly selected patients underwent intratumoral injection of OK-432 mixed with fibrinogen, which was performed on the third preoperative day (OK-432 and fibrinogen plus 5′-deoxy-5-fluorouridine group); eleven patients were given oral 5′-deoxy-5-fluorouridine only (5′-deoxy-5-fluorouridine group). The 5-fluorouracil concentration in tumor tissue and normal colon mucosa tissue was measured, and the influence of the local immunotherapy was assessed. RESULTS: The 5-fluorouracil concentration in the cancer tissue was increased by the local immunotherapy, whereas that in the normal colon mucosa was not influenced. Thus, the influence of local immunotherapy was selective to the cancer tissue where the mixture of OK-432 and fibrinogen was injected. CONCLUSION: In patients with colorectal cancer, selective high 5-fluorouracil concentration in the cancer tissue could be achieved by a combination of 5′-deoxy-5-fluorouridine and local immunotherapy with a mixture of OK-432 and fibrinogen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02258309
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Jejunal carcinoma with adenoma —Report of a case and review of the Japanese literature— (1990)
    Springer
    Surgery today 20 (1990), S. 711-714 
    Details
    ISSN: 1436-2813
    Schlagwort(e): jejunal carcinoma ; jejunal adenoma ; coexisting carcinoma and adenoma ; adenoma-carcinoma sequence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A rare case of jejunal carcinoma coexisting with adenoma, situated 120 cm distal to the ligament of Treitz in a 53 year old male, is reported herein. We also review cases of adenoma and carcinoma in the jejunum and ileum from the Japanese literature, and discuss the histogenesis of carcinoma of the jejunum and ileum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471039
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  • 3
    Digitale Medien
    Digitale Medien
    Detection of microsatellite alterations in nipple discharge accompanied by breast cancer (2000)
    Springer
    Breast cancer research and treatment 60 (2000), S. 35-41 
    Details
    ISSN: 1573-7217
    Schlagwort(e): nipple discharge ; breast cancer ; diagnosis ; loss of heterozygosity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Nipple discharge in breast cancer cases was examined loss of heterozygosity (LOH). DNA samples were extracted from both supernatant and cell pellet components of the discharge, and examined for LOH at microsatellite markers, D11S1818, D11S2000, D16S402, D16S504, D16S518, D17S520, and D17S786. At least one LOH was found in either the supernatant or cell pellet in seven out of 10 patients (70%). Five of seven samples, which were cytologically negative, were LOH positive, and only one case, which was cytologically positive, showed no LOH on the markers examined. All three samples, which were judged ‘negative’ by CEA measurement (〈400 ng/ml), were LOH positive. This method could be a useful novel diagnostic modality for nonpalpable breast cancer with nipple discharge.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006336110322
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