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  • 1
    Electronic Resource
    Electronic Resource
    A randomised, controlled study of peri-operative low dose s(+)-ketamine in combination with postoperative patient-controlled s(+)-ketamine and morphine after radical prostatectomy (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a randomised, double-blind prospective study we compared the effects on postoperative pain and analgesic consumption of intra-operative s(+)-ketamine (100 μg.kg−1 bolus and a continuous infusion of 2 μg.kg−1.min−1) followed by postoperative patient-controlled analgesia with morphine (1 mg per bolus) plus s(+)-ketamine (0.5 mg per bolus), or intra-operative saline followed by postoperative patient-controlled analgesia morphine (1 mg per bolus) alone. A total of 28 male patients undergoing radical prostatectomy were studied. Morphine consumption, pain scores, pressure algometry and adverse effects were recorded for 48 h after surgery. Cumulative morphine consumption was significantly lower in the ketamine/morphine group (47.9 ± 26.2 mg) than in the saline/morphine group (73.4 ± 34.8 mg; p = 0.049). Pain scores at rest were significantly lower in the ketamine/morphine group across the 48-h study period (p = 0.01). No significant differences were found in pressure algometry measurements or the occurrence of adverse effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2003.03620.x
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  • 2
    Electronic Resource
    Electronic Resource
    Basement-Cover Sequences within the UHP unit of the Dabie Shan (2003)
    Oxford, UK : Blackwell Science Inc
    Journal of metamorphic geology 21 (2003), S. 0 
    Details
    ISSN: 1525-1314
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Field data define two lithologically distinct basement-cover sequences within the ultrahigh-pressure metamorphic (UHPM) unit of the Dabie Shan, eastern China. One of the cover units, the Changpu unit, comprises calc-arenitic metasediments in stratigraphic contact with a basement consisting of gneisses of the Yangtze craton. The second cover unit, the Ganghe unit, consists of felsic-intermediate metavolcanics and clastic metasediments. Basement exposure of the Ganghe unit is not known. Fold axes in the Ganghe unit are oblique to those of the Changpu unit, which are parallel to those of the Yangtze gneisses. Preservation of primary textures in some volcanic rocks, and tectonic separation from the Yangtze gneisses by a greenschist facies mylonite, support an interpretation of the Ganghe unit as a low-strain domain. Protolith associations in the Ganghe and Changpu units are compatible with deposition in a rift setting and along a passive continental margin, respectively. A U–Pb single zircon age of 761 ± 33 Ma for volcanoclastic rocks of the Ganghe unit demonstrates a Neoproterozoic deposition age, concordant with inferred rifting at that time. Eclogite facies parageneses in the gneisses and both cover units, along with P–T data demonstrate regional UHPM in the Dabie Shan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1314.2003.00461.x
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  • 3
    Electronic Resource
    Electronic Resource
    Über einige Sulfidfluoride der Seltenen Erden (1965)
    Springer
    Naturwissenschaften 52 (1965), S. 475-475 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626236
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  • 4
    Electronic Resource
    Electronic Resource
    Interaction of Bilirubin with Albumin (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 1041-1043 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 'Sephadex' gel-filtration was used to separate albumin; bound bilirubin from unbound pigment; the bilirubin?albumin complex passed through the gel rapidly, while the smaller molecules of unbound pigment remained on the column. Therefore, the maximum binding capacity of the protein could be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2061041b0
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  • 5
    Electronic Resource
    Electronic Resource
    Reporter gene bioassays in environmental analysis (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 769-779 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In parallel to the continuous development of increasingly more sophisticated physical and chemical analytical technologies for the detection of environmental pollutants, there is a progressively more urgent need also for bioassays which report not only on the presence of a chemical but also on its bioavailability and its biological effects. As a partial fulfillment of that need, there has been a rapid development of biosensors based on genetically engineered bacteria. Such microorganisms typically combine a promoter-operator, which acts as the sensing element, with reporter gene(s) coding for easily detectable proteins. These sensors have the ability to detect global parameters such as stress conditions, toxicity or DNA-damaging agents as well as specific organic and inorganic compounds. The systems described in this review, designed to detect different groups of target chemicals, vary greatly in their detection limits, specificity, response times and more. These variations reflect on their potential applicability which, for most of the constructs described, is presently rather limited. Nevertheless, present trends promise that additional improvements will make microbial biosensors an important tool for future environmental analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051571
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  • 6
    Electronic Resource
    Electronic Resource
    Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma (2000)
    Springer
    Archives of dermatological research 292 (2000), S. 225-232 
    Details
    ISSN: 1432-069X
    Keywords: Key words Melanoma ; Melanoma-metastases ; Bcl-2 ; Bcl-x ; Bax
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Apoptosis is an important cofactor in the pathogenesis of a plethora of malignancies. However, little is known about modulation of the expression of bcl gene family in melanocytic tumors. To determine the role of bcl-2, bcl-x and bax in melanocytic tumors we investigated the differential expression of these genes via RT-PCR in tissue samples from human ¶benign nevi, primary melanomas and melanoma metastases in comparison with normal skin. Bcl-2 was strongly expressed in 14/16 metastases (87.5%), whereas only 7/13 primary melanomas (53%), 7/15 nevi (46%) and 7/16 normal tissue samples (43%) showed expression of bcl-2 (P 〈 0.05). There was a strong indication of a correlation between tumor thickness and bcl-2 expression in nodular malignant melanomas. Expression of bcl-x was found in 16/16 melanoma metastases (100%), 11/13 primary melanomas (84%), 12/15 nevi (80%) and 10/16 normal tissue samples (62%) (P 〈 0.05). Bcl-xL expression increased from primary melanoma to melanoma metastases, whereas bcl-xS showed a decreasing expression level during melanoma progression. No differences in bax expression were seen between melanoma metastases, primary melanoma, nevi and normal tissue. Immunohistochemical investigations of another 53 tissue samples showed similar results. Our results strongly indicate that bcl-2 and bcl-xL gene expression increases with progression of malignant melanoma. Bcl-2 and bcl-xL expression could reflect an increased malignant potential caused by an inhibition of apoptosis and growth advantage for metastatic melanoma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050479
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  • 7
    Electronic Resource
    Electronic Resource
    Über einige Bedingungen des Zusammenhanges von Lidschlag und Blickwendung (1969)
    Springer
    Psychological research 33 (1969), S. 68-78 
    Details
    ISSN: 1430-2772
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Description / Table of Contents: Zusammenfassung Der Zusammenhang zwischen Blickwendung und Lidschlag wurde experimentell untersucht. Als wirksame Faktoren erwiesen sich die Größe der Blickwendung, die Kopfbewegung, die Art der Wahrnehmungsobjekte (Person — Gegenstand) und bei Personen der Grad der Aufmerksamkeitszuwendung. Über alle Versuchsbedingungen hinweg zeigte sich die relative Häufigkeit des Lidschlages bei der Blickwendung als individuell konstant.
    Notes: Summary The relationship between gaze movement and eye blink was investigated. The angle of eye movement, movement of the head, the type of objects perceived (person-object) and (when persons were viewed) the degree of attention were found to be relevant factors. Under all conditions studied, the relative frequency of blinking during gaze movement was shown to be individually constant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00424617
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  • 8
    Electronic Resource
    Electronic Resource
    Synthesen von Heterocyclen, 98. Mitt.: Zur Chemie der Ketenimine (1967)
    Springer
    Monatshefte für Chemie 98 (1967), S. 1954-1961 
    Details
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Abstract Diaryl ketenimines react with monosubstituted malonyl chlorides to 2-oxo-chromeno[3.2-b]pyrroles (1–7), and dialkyl ketenimines to 4.5-dihydro-5-oxo-2H-furo[3.2-b]pyrroles (11–12).
    Notes: Zusammenfassung Diaryl-ketenimine reagieren mit monosubstit. Malonsäurechloriden unter Abgabe von 2 HCl zu 2-Oxo-chromeno-[3,2-b]pyrrolen (1–7), Dialkyl-ketenimine dagegen zu 4,5-Dihydro-5-oxo-2H-furo[3,2-b]pyrrolen (11–12).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01167158
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  • 9
    Electronic Resource
    Electronic Resource
    Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection (2000)
    Springer
    Transplant international 13 (2000), S. S324 
    Details
    ISSN: 1432-2277
    Keywords: Key words Fas ligand ; Gene transfer ; Low-dose immunosuppression ; Lung allograft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction between Fas and its ligand (FasL) induces apoptosis in the Fas-expressing cell. We hypothesized that liposome-mediated FasL gene transduction to the lung allograft, in addition to low-dose immunosuppression, might reduce acute rejection. Orthotopic left lung allotransplantation was performed in male rats (Brown Norway to Fischer F344). FasL gene transfer was performed by use of the plasmid pBCMGSNeo carrying the gene coding for murine FasL and the cationic liposome GL#67:DOPE. Six hundred and sixty micrograms of DNA in 250 μl H2O and 0.5 μmol GL#67 in 250 μl H2O were diluted to 5 ml with saline solution. This emulsion (20 °C) was instilled retrogradely through the left pulmonary vein after flushing with LPD solution (20 ml, at 4 °C). Subsequently, the graft was stored at 10 °C for 3 h. A single dose of cyclosporine A (CsA; 2.5 mg/kg i. m.) was given to all groups 48 h after the transplantation. In group 1 (n = 6), FasL/GL#67 was instilled as described. In group 2 (n = 5), GL#67 was given without DNA. Group 3 (n = 5) animals received CsA only. Five days after transplantation, gas exchange was assessed after exclusion of the contralateral native lung (FiO2 = 1.0). Grafts were flushed with saline solution and fixed in formaldehyde for histological evaluation. No statistical difference in gas exchange (PaO2) between the two control groups 2 (6.4 ± 0.4 kPa) and 3 (7.4 ± 0.4 kPa) could be detected 5 days postoperatively (P = 0.9). In contrast, grafts transduced with FasL (group 1) had significantly better gas exchange on postoperative day 5 (PaO2: group 1 37.0 ± 10.6 kPa vs group 2 6.4 ± 0.41 kPa; P = 0.002). Two animals in group 1 revealed no or only minimal improvement in gas exchange. Histologically, all lung specimen of all groups showed signs of acute rejection (A2). Leukocyte infiltrates, rated by two independent observers, were less severe in all group 1 animals. Liposome-mediated FasL gene transfer at the time of harvest in combination with low-dose CsA reduces acute rejection in four out of six animals in this model of rat lung allotransplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050353
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  • 10
    Electronic Resource
    Electronic Resource
    Die Änderung der Elektronenstruktur des Nickels durch Wasserstoffbeladung (1966)
    Springer
    The European physical journal 190 (1966), S. 10-15 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract TheK-absorption spectrum of nickel charged with hydrogen has been investigated using a Bragg spectrograph with photographic registration. The fine structure of the absorption edge of the nickel hydride as compared with that of nickel shows that the electrons of the dissolved hydrogen fill up the empty 3d- and 4s-states of the conduction band of the metal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01340345
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