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  • 1
    Electronic Resource
    Electronic Resource
    Mechanism of hydrolysis of N-methylacetimidate esters (1968)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 90 (1968), S. 7072-7076 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01027a033
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  • 2
    Electronic Resource
    Electronic Resource
    Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To assess the efficacy and safety of enteric coated capsules containing a fixed combination of 90 mg peppermint oil and 50 mg caraway oil (PCC; Enteroplant) in patients with functional dyspepsia.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:A total of 96 out-patients received one capsule twice daily of PCC or placebo for 28 days. Primary efficacy variables were the intra-individual change in (i) pain intensity and (ii) sensation of pressure, heaviness and fullness between days 1 and 29, and the investigators’ rating of (iii) global improvement (Clinical Global Impressions [CGI] item 2) on day 29. A global type I error of α=0.05 was controlled by a priori ordering of hypotheses.〈section xml:id="abs1-3"〉〈title type="main"〉Results:All patients were evaluable for efficacy and safety. On day 29, the average intensity of pain was reduced by 40% vs. baseline in the PCC group and by 22% in the placebo group. With regards to pressure, heaviness and fullness, a 43% reduction was observed for PCC vs. 22% for placebo. In CGI item 2, 67% (PCC) vs. 21% (placebo) of the patients were described as much or very much improved. In all three target parameters, the superiority of PCC over placebo was statistically significant. Six patients (PCC: 5; placebo: 1) reported adverse events, either unrelated to the trial, or attributable to an aggravation of the disease under investigation. Eructation with peppermint taste did not occur.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:These results demonstrate the good tolerability and the favourable risk–benefit ratio of PCC for the treatment of functional dyspepsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00873.x
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on the pathogeneicity of Listeria monocytogenes (1991)
    Springer
    Infection 19 (1991), S. S195 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Charakterisierung vonL. monocytogenes Mutanten mit verminderter Virulenz wird beschrieben. Mutanten mit reduzierter Synthese des extrazellulären Proteins p60 (kodiert von dem iap Gen) bilden lange septierte Zellfilamente, die erheblich weniger invasiv für nichtprofessionell phagozytische Animalzellen sind als der Wildstamm. Mutanten, die kein Listeriolysin bilden, sind zwar noch invasiv, können aber in phagozytischen Zellen nicht mehr überleben. Ein Typ dieser Listeriolysin-negativen Mutanten weist eine Mutation in einem Gen (prfA) auf, das einen positiv wirkenden Transkriptionsregulatur (PrfA) kodiert, der das Listeriolysingen (lisA) und mehrere andere Gene koordiniert reguliert. Dazu gehören Gene für eine Phosphatidylinositol-spezifische Phospholipase und eine Metalloprotease.
    Notes: Summary The characterization of mutants ofListeria monocytogenes with reduced virulence properties is described. Reduction in the amount of the extracellular protein p60 (encoded by the ipa gene) leads to cell filaments with impaired invasiveness. Mutants which cannot synthesize listeriolysin are still invasive but unable to survive within phagocytic cells. One type of listeriolysin-negative mutants is defective in the synthesis of a positive regulatory element PrfA which coordinately regulates the listeriolysin gene (lisA) together with several other genes, including those for a phosphatidylinositol-specific phospholipase and a metalloprotease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644032
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  • 4
    Electronic Resource
    Electronic Resource
    X-ray diffraction moiré topography as a means to reconstruct relative displacement fields in weakly deformed bicrystals (1999)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 423-432 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: X-ray diffraction topographs of wafers produced by separation by implanted oxygen (SIMOX) show moiré fringes in both reflection and transmission geometry. These fringes reveal deformations of the order of 10−6 to 10−8 between the layer and the substrate of the SIMOX material. A new method for a quantitative analysis of moiré fringes is developed and allows reconstruction with a high sensitivity of the three components of the relative displacement field between layer and substrate directly from a set of topographs. This method is used for the interpretation of moiré topographs of entire 4 in SIMOX wafers and of regions around crystal defects. Finally, the capabilities of an analysis of moiré fringes are compared with those of the usual diffraction topography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767398010794
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  • 5
    Electronic Resource
    Electronic Resource
    Reporter gene bioassays in environmental analysis (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 769-779 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In parallel to the continuous development of increasingly more sophisticated physical and chemical analytical technologies for the detection of environmental pollutants, there is a progressively more urgent need also for bioassays which report not only on the presence of a chemical but also on its bioavailability and its biological effects. As a partial fulfillment of that need, there has been a rapid development of biosensors based on genetically engineered bacteria. Such microorganisms typically combine a promoter-operator, which acts as the sensing element, with reporter gene(s) coding for easily detectable proteins. These sensors have the ability to detect global parameters such as stress conditions, toxicity or DNA-damaging agents as well as specific organic and inorganic compounds. The systems described in this review, designed to detect different groups of target chemicals, vary greatly in their detection limits, specificity, response times and more. These variations reflect on their potential applicability which, for most of the constructs described, is presently rather limited. Nevertheless, present trends promise that additional improvements will make microbial biosensors an important tool for future environmental analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051571
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  • 6
    Electronic Resource
    Electronic Resource
    Resonance ionization mass spectroscopy for trace determination of plutonium in environmental samples (1997)
    Springer
    Fresenius' journal of analytical chemistry 359 (1997), S. 378-381 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  Resonance ionization mass spectroscopy (RIMS) is a sensitive and isotope selective method and well suited for trace analysis of plutonium in the environment. After the chemical isolation of plutonium from soil, air filters or urine, e.g., it is electrolytically deposited as hydroxide on a tantalum backing and covered with a thin titanium layer. By heating such a sandwich filament in the RIMS-apparatus under vacuum an atomic beam of plutonium is produced. The atoms are ionized by a three-step resonant excitation using pulsed dye lasers, and the ions are mass-selectively detected with a time-of-flight (TOF) spectrometer and a multi channel plate detector. RIMS yields a low detection limit of 106–107 atoms and a high element and isotope selectivity. This technique has been used for the investigation of soil samples from the Chernobyl area, sediments from the Mururoa Atoll and urine samples with respect to the total amount of plutonium and its isotopic composition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050591
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  • 7
    Electronic Resource
    Electronic Resource
    Das Informationssystem ISRA/R in der gynäkologischen Endokrinologie (1989)
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 1129-1131 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vorgestellt wird ein Informationssystem für die Unterstützung der klinischen Forschung in der Reproduktionsmedizin (ISRA/R). Dieses System basiert auf einer Datenbank, in der alle in unserem Zentrum anfallenden Daten sofort im On-Line Betrieb erfaßt werden. Dadurch steht uns ein Werkzeug zur Verfügung, das sowohl den Ablauf des täglichen Routinebetriebes als auch die Durchführung klinischer Studien erheblich vereinfacht hat.
    Notes: Summary This paper presents an information system for the support of clinical research in reproductive medicine (ISRA/R). The system is established on a database approach — all data arising at our center is instantly recorded on-line into the database. Thus a mighty tool has been established to aid us considerably in our daily work as well as in clinical studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02417720
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  • 8
    Electronic Resource
    Electronic Resource
    A subtype of the prototypic karyotype in acute myeloid leukemia t (8; 21) (q22; q22), del 9 (q13; q23) (1980)
    Springer
    Annals of hematology 40 (1980), S. 27-32 
    Details
    ISSN: 1432-0584
    Keywords: Subtyp ; typischer Karyotyp ; AML ; Subtype ; Prototypic karyotype ; AML
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Two patients with acute myeloid leukemia are described in whom G- and C-banding analysis of bone marrow cells revealed, besides the translocation t(8;21), an additional structural anomaly characterized by the deletion of bands q13 to q23 of one chromosome no. 9. Findings in the literature support the proposal that this constellation represents a hitherto unreported subtype of the prototypic karyotype in AML.
    Notes: Zusammenfassung Bei zwei Patienten mit akuter myeloischer Leukämie wurde durch die G- und C-Bandenanalyse der Knochenmarkzellen neben der Translokation t(8;21) eine zusätzliche strukturelle Anomalie nachgewiesen, die durch die Deletion der Banden q13 bis q23 eines Chromosoms Nr. 9 gekennzeichnet ist. Diese Konstellation stellt einen Subtyp des typischen Karyotyps der AML dar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01028361
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  • 9
    Electronic Resource
    Electronic Resource
    Shockwave application in calcifying tendinitis of the shoulder – prediction of outcome by imaging (2000)
    Springer
    Archives of orthopaedic and trauma surgery 120 (2000), S. 493-498 
    Details
    ISSN: 1434-3916
    Keywords: Key words Shoulder ; Calcifying tendinitis ; Shock wave ; MRI ; Prediction parameters ; Clinical outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This prospective study examined 62 patients (65 shoulders) with chronic courses of calcifying tendinitis of the shoulder before and after low-energy extracorporeal shockwave application (ESWA) in order to identify variables associated with the outcome of this treatment. Before ESWA, radiographs and contrast-enhanced magnetic resonance imaging (MRI) of the affected shoulders were obtained in order to document the size and morphology of the calcifications and the contrast media reactions in areas of interest (deposit, synovia, bursae), respectively. In addition, a clinical evaluation was performed. After ESWA (mean follow-up 18.2 months), clinical evaluations of all 65 shoulders revealed an increase in the Constant score from 44% to 78% (p 〈 0.0001). While size (p = 0.61) and morphology (p = 0.7) of the deposits before ESWA were not associated with the clinical outcome, negative contrast reactions around the deposits (p = 0.0001), synovia (p = 0.0049) and bursae (p 〈 0.01) were associated with improved clinical outcomes. After the total study group was divided into two groups, one with Constant scores ≥ 75% (n = 43) and the other with scores 〈 75% (n = 22), the positive predictive value (ppv), specificity (sp) and sensitivity (se) were determined for the negative reaction around the deposit (ppv: 0.94; sp: 0.95; se: 0.38), synovia (ppv: 0.84; sp: 0.82; se: 0.49) and bursae (ppv: 0.86; sp: 0.86; se: 0.44). In 5 cases (7.7%), surgery of the affected shoulder during the follow-up period was performed. No major side-effects were seen in the study group. In conclusion, our results suggest that in patients with chronic calcifying tendinitis, the absence of contrast enhancement, especially around the deposit, is a strong predictive parameter of a positive clinical outcome of ESWA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004020000154
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  • 10
    Electronic Resource
    Electronic Resource
    Plant regeneration by organogenesis in Glycine max (1986)
    Springer
    Plant cell reports 5 (1986), S. 150-154 
    Details
    ISSN: 1432-203X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A procedure for the regeneration of fertile plants by organogenesis from tissue cultures of soybeans, Glycine max is described. Seeds were germinated on reduced inorganic salt MS medium containing 5μM BA. Cotyledonary nodes were excised and cultured on the same medium. Presence of BA in the medium during seed germination and culture of nodal explants was required for multiple shoot and shoot-bud formation. Histological analyses established the de novo nature of shoot regeneration. Separate reduction of the concentration of inorganic salts or substitution of sucrose for fructose during culture had minimal effects on the regeneration response. Conversely, if the BA was reduced, the inhibition response could not be overcome by increased salt concentration or altered carbon source.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00269257
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