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  • 1
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 90 (1968), S. 7072-7076 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: To assess the efficacy and safety of enteric coated capsules containing a fixed combination of 90 mg peppermint oil and 50 mg caraway oil (PCC; Enteroplant) in patients with functional dyspepsia.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:A total of 96 out-patients received one capsule twice daily of PCC or placebo for 28 days. Primary efficacy variables were the intra-individual change in (i) pain intensity and (ii) sensation of pressure, heaviness and fullness between days 1 and 29, and the investigators’ rating of (iii) global improvement (Clinical Global Impressions [CGI] item 2) on day 29. A global type I error of α=0.05 was controlled by a priori ordering of hypotheses.〈section xml:id="abs1-3"〉〈title type="main"〉Results:All patients were evaluable for efficacy and safety. On day 29, the average intensity of pain was reduced by 40% vs. baseline in the PCC group and by 22% in the placebo group. With regards to pressure, heaviness and fullness, a 43% reduction was observed for PCC vs. 22% for placebo. In CGI item 2, 67% (PCC) vs. 21% (placebo) of the patients were described as much or very much improved. In all three target parameters, the superiority of PCC over placebo was statistically significant. Six patients (PCC: 5; placebo: 1) reported adverse events, either unrelated to the trial, or attributable to an aggravation of the disease under investigation. Eructation with peppermint taste did not occur.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:These results demonstrate the good tolerability and the favourable risk–benefit ratio of PCC for the treatment of functional dyspepsia.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 423-432 
    ISSN: 1600-5724
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: X-ray diffraction topographs of wafers produced by separation by implanted oxygen (SIMOX) show moiré fringes in both reflection and transmission geometry. These fringes reveal deformations of the order of 10−6 to 10−8 between the layer and the substrate of the SIMOX material. A new method for a quantitative analysis of moiré fringes is developed and allows reconstruction with a high sensitivity of the three components of the relative displacement field between layer and substrate directly from a set of topographs. This method is used for the interpretation of moiré topographs of entire 4 in SIMOX wafers and of regions around crystal defects. Finally, the capabilities of an analysis of moiré fringes are compared with those of the usual diffraction topography.
    Materialart: Digitale Medien
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  • 4
    ISSN: 1432-0649
    Schlagwort(e): 32.30.—r ; 32.80.Rm ; 32.80.Dz ; 35.10.Hn
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Resonance ionization mass spectroscopic (RIMS) measurements for trace analysis and spectroscopy of 237Np, the ecologically most important isotope of neptunium, are described. The chemical procedure for the separation of neptunium from aqueous samples as well as the preparation of filaments for RIMS are outlined. Several two- and three-step excitation schemes have been investigated in order to find suitable conditions for the sensitive detection of 237Np. Using a three-step, three-color excitation and ionization scheme an overall detection efficiency of 3×10−8 was obtained, resulting in a detection limit of 4×108 atoms (160 fg) of 237Np. The hyperfine structure splittings of the levels under investigation, which influence the detection limit, were measured. A new method to determine the first ionization potential (IP) was applied to neptunium yielding a value of IP=6.2655(2) eV.
    Materialart: Digitale Medien
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  • 5
    ISSN: 1434-3916
    Schlagwort(e): Key words Shoulder ; Calcifying tendinitis ; Shock wave ; MRI ; Prediction parameters ; Clinical outcome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This prospective study examined 62 patients (65 shoulders) with chronic courses of calcifying tendinitis of the shoulder before and after low-energy extracorporeal shockwave application (ESWA) in order to identify variables associated with the outcome of this treatment. Before ESWA, radiographs and contrast-enhanced magnetic resonance imaging (MRI) of the affected shoulders were obtained in order to document the size and morphology of the calcifications and the contrast media reactions in areas of interest (deposit, synovia, bursae), respectively. In addition, a clinical evaluation was performed. After ESWA (mean follow-up 18.2 months), clinical evaluations of all 65 shoulders revealed an increase in the Constant score from 44% to 78% (p 〈 0.0001). While size (p = 0.61) and morphology (p = 0.7) of the deposits before ESWA were not associated with the clinical outcome, negative contrast reactions around the deposits (p = 0.0001), synovia (p = 0.0049) and bursae (p 〈 0.01) were associated with improved clinical outcomes. After the total study group was divided into two groups, one with Constant scores ≥ 75% (n = 43) and the other with scores 〈 75% (n = 22), the positive predictive value (ppv), specificity (sp) and sensitivity (se) were determined for the negative reaction around the deposit (ppv: 0.94; sp: 0.95; se: 0.38), synovia (ppv: 0.84; sp: 0.82; se: 0.49) and bursae (ppv: 0.86; sp: 0.86; se: 0.44). In 5 cases (7.7%), surgery of the affected shoulder during the follow-up period was performed. No major side-effects were seen in the study group. In conclusion, our results suggest that in patients with chronic calcifying tendinitis, the absence of contrast enhancement, especially around the deposit, is a strong predictive parameter of a positive clinical outcome of ESWA.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1432-0584
    Schlagwort(e): Subtyp ; typischer Karyotyp ; AML ; Subtype ; Prototypic karyotype ; AML
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Two patients with acute myeloid leukemia are described in whom G- and C-banding analysis of bone marrow cells revealed, besides the translocation t(8;21), an additional structural anomaly characterized by the deletion of bands q13 to q23 of one chromosome no. 9. Findings in the literature support the proposal that this constellation represents a hitherto unreported subtype of the prototypic karyotype in AML.
    Notizen: Zusammenfassung Bei zwei Patienten mit akuter myeloischer Leukämie wurde durch die G- und C-Bandenanalyse der Knochenmarkzellen neben der Translokation t(8;21) eine zusätzliche strukturelle Anomalie nachgewiesen, die durch die Deletion der Banden q13 bis q23 eines Chromosoms Nr. 9 gekennzeichnet ist. Diese Konstellation stellt einen Subtyp des typischen Karyotyps der AML dar.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 50 (1994), S. 793-794 
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
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  • 8
    ISSN: 1432-1130
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract  Resonance ionization mass spectroscopy (RIMS) is a sensitive and isotope selective method and well suited for trace analysis of plutonium in the environment. After the chemical isolation of plutonium from soil, air filters or urine, e.g., it is electrolytically deposited as hydroxide on a tantalum backing and covered with a thin titanium layer. By heating such a sandwich filament in the RIMS-apparatus under vacuum an atomic beam of plutonium is produced. The atoms are ionized by a three-step resonant excitation using pulsed dye lasers, and the ions are mass-selectively detected with a time-of-flight (TOF) spectrometer and a multi channel plate detector. RIMS yields a low detection limit of 106–107 atoms and a high element and isotope selectivity. This technique has been used for the investigation of soil samples from the Chernobyl area, sediments from the Mururoa Atoll and urine samples with respect to the total amount of plutonium and its isotopic composition.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 769-779 
    ISSN: 1432-1130
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract In parallel to the continuous development of increasingly more sophisticated physical and chemical analytical technologies for the detection of environmental pollutants, there is a progressively more urgent need also for bioassays which report not only on the presence of a chemical but also on its bioavailability and its biological effects. As a partial fulfillment of that need, there has been a rapid development of biosensors based on genetically engineered bacteria. Such microorganisms typically combine a promoter-operator, which acts as the sensing element, with reporter gene(s) coding for easily detectable proteins. These sensors have the ability to detect global parameters such as stress conditions, toxicity or DNA-damaging agents as well as specific organic and inorganic compounds. The systems described in this review, designed to detect different groups of target chemicals, vary greatly in their detection limits, specificity, response times and more. These variations reflect on their potential applicability which, for most of the constructs described, is presently rather limited. Nevertheless, present trends promise that additional improvements will make microbial biosensors an important tool for future environmental analysis.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 1129-1131 
    ISSN: 1432-0711
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Vorgestellt wird ein Informationssystem für die Unterstützung der klinischen Forschung in der Reproduktionsmedizin (ISRA/R). Dieses System basiert auf einer Datenbank, in der alle in unserem Zentrum anfallenden Daten sofort im On-Line Betrieb erfaßt werden. Dadurch steht uns ein Werkzeug zur Verfügung, das sowohl den Ablauf des täglichen Routinebetriebes als auch die Durchführung klinischer Studien erheblich vereinfacht hat.
    Notizen: Summary This paper presents an information system for the support of clinical research in reproductive medicine (ISRA/R). The system is established on a database approach — all data arising at our center is instantly recorded on-line into the database. Thus a mighty tool has been established to aid us considerably in our daily work as well as in clinical studies.
    Materialart: Digitale Medien
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