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Digitale Medien

Identification of the proto-oncogene c-fos in areas of periprosthetic osteolysis around loosened hip prostheses (2000)

Chiba, C. ; Chiba, J. ; Oyama, M. ; [weitere]

Springer

Modern rheumatology 10 (2000), S. 225-229

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Details

ISSN: 1439-7609

Schlagwort(e): Key words Proto-oncogene c-fos ; Interfacial membrane ; Osteolysis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Expression of the proto-oncogene c-fos was investigated by in situ hybridization and a study of the immunohistochemistry of the interfacial membranes surrounding the femoral component of failed cementless total hip arthroplasty (THA). The values of the proto-oncogene c-fos gene and protein were high in these interfacial membranes. High expression of the c-fos gene and protein was observed in the macrophage-like cells and fibroblast-like cells. However, there was little expression in multinucleated giant cells. We demonstrated the significance of the proto-oncogene c-fos in interfacial membranes – the first report of c-fos in total joint replacement failure.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s101650070007

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