ISSN:
1573-7284
Keywords:
Human hepatitis A virus
;
T1oligonucleotide fingerprinting
;
Genomic stability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Three human hepatitis A virus strains, all of them isolated in Italy but one acquired abroad, were analyzed by T1 - RNAase oligonucleotide mapping and by monoclonal antibody neutralization. The variation among their genomes according to T1 - maps was calculated to be about 9%, thus confirming the poor genomic variation assessed by nucleotide sequencing (1 – 10%). However T1 - maps of these Italian isolates were different from those reported in the literature (Weitz and Siegl, 1985). Neutralization by monoclonal antibody caused a reduction in titres of 2 – 2.5 log10. This genomic stability, if confirmed, is important with a view to a valuable vaccine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00155545
Permalink
