ISSN:
1352-8661
Keywords:
diffusion-weighted MRI
;
susceptibility contrast MRI
;
ischemia
;
brain
;
blood flow
;
cat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
Notes:
Abstract Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis.T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01705274
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