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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 80 (2002), S. 3036-3038 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We demonstrate a compact, broadband optical amplifier using the conjugated polymer poly[2-methoxy-5-(2′,6′-dimethyloctyloxy)-paraphenylenevinylene] (OC1C10–PPV) in dilute solution. Gains of 30–40 dB in a wavelength range of 575–640 nm, corresponding to a 50 THz bandwidth, are observed due to the broad luminescence spectrum and large cross section for stimulated emission of the polymer. The variation in gain as a function of solution concentration and probe intensity is examined. For a 1 cm path length we observe a small signal gain of 44±1 dB, and deduce a stimulated emission cross-section for OC1C10–PPV of (5.3±0.6)×10−17 cm2. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 19 (1999), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: We have developed a rugged, durable platinum wire Eh electrode for application in subsurface environments. The electrode design is described in detail and its performance under aerobic and anaerobic steady-state and transient conditions is assessed. The electrode consists of a 0.5-mm-diameter platinum wire (99.99% purity) cast in a glass fiber-reinforced epoxy jacket. The construction allowed installation through direct insertion into sandy media to depths up to several meters. Data collection was through connection to a datalogger with high impedance input; data points were collected every 10 seconds and averaged and stored once an hour. The electrodes functioned in situ for periods of more than three years and gave reliable readings during oxic, anoxic, and transitional conditions. Performance testing and examination of electrodes recovered after three years in situ indicated that they were not impacted by corrosion, dissolution, or poisoning.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: A mesoscale model soil and ground-water system was constructed and instrumented to study physical, chemical, and microbial processes, including transport and degradation of contaminants. The model system was 4.6 m in height by 2.4 m in diameter and contained up to 65 tonnes of soil and geologic materials. The model was filled with Ap (11 cm), B (20 cm), C1 and C2 (369 cm) horizons; the water table was 3.3 m from the soil surface. A rain simulation system applied uniform coverage of rain and/or chloride tracer to the model. Sampling of soil, sediment, pore waters, and gas phase was carried out using a series of in situ collectors and sampling ports. Major anions, metals, pH, alkalinity, CO2, N2, O2, CH4, microbial numbers, microbial biomass and heterotrophic potential (14 C-amino-acid uptake) were monitored over time (120 days) and depth. The system approached steady state with respect to solution chemistry and gases after approximately 60–70 days. During this interval, carbon dioxide rose from atmospheric to 3–5% of total gas volume measured at each sampling depth above the water table. Physical, chemical, and biological conditions in the model system after the initial 120 days were comparable to those reported for vadose and saturated zones during field studies on shallow phreatic aquifers. These results indicated that the mesoscale model preserved many of the features of natural systems while providing controlled conditions for studies such as evaluating the fate, and ground-water contamination potential, of agricultural and industrial chemicals.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 37 (1999), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Transport of the bacteria Klebsiella oxytoca and Burkholderia cepacia G4PR1 (G4PR1) was investigated in column experiments conducted under conditions that allowed us to quantify sorption under a range of ground water velocities. Column experiments (33 mm I.D. × 114 mm long columns) were conducted at four linear water velocities (0.5 to 14 cm.hr−1) through a medium to coarse grained silica sand. The peak C/Co concentrations for both bacteria were attenuated with respect to a conservative tracer (Cl−), and well-defined tailing was observed. Breakthroughs of both bacteria were influenced by the water velocity. In the case of G4PR1, the attenuation of the peak C/Co concentrations increased as the velocity decreased while the peak C/Co concentrations for K. oxytoca were similar at velocities between 3 and 13 cmhr−1 but decreased at the lowest velocity tested (0.6 cm-hr−1). The tailing reached constant C/Co values of between 2 × 10−3 and 5 × 10−3, and between 2 × 10−5 and 5 × 10−5 for K. oxytoca and G4PR1 after 2t0. A one-dimensional mathematical model for advective-dispersive transport that accounts for irreversible (kirr) and reversible (kf and kr) sorption was used to quantify the sorption process. Both irreversible and reversible sorption was required to obtain good fits to the measured K. oxytoca data. Results of this modeling suggested that kirr and kr are independent of velocity and an empirical relationship was developed relating kf to velocity. For G4PR1, the best fits were obtained using only reversible sorption. Results of the modeling suggested that kf was independent of velocity at all velocities tested and kr was independent of velocity at velocities between 3 and 13 cmhr−1. At the lowest velocity investigated (0.5 cmhr−1), the kf value decreased considerably. This study showed that sorption characteristics are bacteria specific, and are likely related to surface chemistry because G4PR1 is more hydrophobic than K. oxytoca. The study also showed that in order for bacterial transport experiments to be directly applicable to the subsurface, they should be conducted at velocities similar to those observed in the subsurface, or the relationship between the sorption parameter(s) and velocity should be known.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 35 (1997), S. 0 
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Experiments were conducted to investigate the role of sorption during the transport of the bacterium Klebsiella oxytoca through saturated silica sand. The sorption process was visualized at the pore scale in a minicell (3 mm deep × 6.0 mm wide × 7.0 cm long) using scanning confocal laser microscopy. The sorption process was also studied by conducting column experiments at three scales (3.8, 10, and 40 cm long). Results of image analyses of the sorbed and unattached cells in pore throats and the bacterial breakthrough data from the column experiments exhibited similar trends. Breakthrough peaks were attenuated with respect to the input concentrations and well-defined tailing was observed. Visualization suggested that the sorption process was dominated by reversible and irreversible sorption (kirr). In the case of reversible sorption, the rate of forward sorption (kf) was different from the rate for reversible sorption (kr). Visualization also showed that the bacterial coverage on the sand grains, although extensive, covered 〈 0.5% of the available surface area. A 1D solution for advective-dispersive transport was used to estimate kirr, kf, and kr with appropriate values for the coefficient of hydrodynamic dispersion and average linear pore-water velocity (determined from CI data). Simulated best fits to the bacterial peaks were good for the 3.8 cm columns but underestimated peak heights in the 10 and 40 cm columns by one order of magnitude. Best-fit kirr values decreased with increasing scale (0.6,0.13, and 0.062 hr-1 for the 3.8,10, and 40 cm columns, respectively) and showed that a kirr value determined at one scale cannot be used to determine concentrations of K. oxytoca with time at another scale. These results suggested that kirr was a function of to (length of column over velocity). The equivalent irreversible sorption parameter (A, where A = to· kirr) was a constant (mean value of 3.36) for the three scales investigated. This observation suggested that the use of the value A, determined at one scale of investigation, may prove effective in approximating the value of kirr predicting bacterial transport at other scales. Best-fit determinations yielded the same kf and kr values at all three scales (0.1 and 0.02 hr-1). This suggested that reversible sorption may be independent of column length. This study emphasized the need for more comprehensive investigations of the role of sorption in the transport of microorganisms in the subsurface.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The principal cause of 18O depletion, Ca2+ increases, and Mg2+ decreases in the pore fluids of cores from leg 35 of the Deep Sea Drilling Project (DSDP) is the alteration of basalt, volcanic ash, and igneous components of terrigenous material. ...
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The absorption of oral methotrexate in syrup form has been compared in six patients with that of an identical IV dose (50 mg/m2). There was variable absorption amongst the group with respect to maximum levels achieved and the time taken to reach those levels. The area under the time-concentration curve was always smaller when the drug was given orally than after IV administration. A total of 33 patients receiving methotrexate for a variety of tumour types were followed for response to treatment and toxicity. A significantly longer methotrexate half-life (t1/2) was found in nine partial responders (9.2±1.6 h) than in the nonresponders (3.8±0.7 h). Severe methotrexate toxicity was not seen, though occasional mucositis, conjunctivitis, and diarrhoea occurred in seven patients. The side effects could not be predicted from the dose, the bioavailability data, or the serum creatinine. Measurements of serum and urine methotrexate levels are useful in the assessment of absorption and bioavailability of the drug and the prediction of tumour response.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The first hydrothermal fluid samples collected along the slow-spreading Mid-Atlantic Ridge (MAR) are remarkably similar in composition and temperature to fluids collected along the shallower, faster-spreading East Pacific Rise (EPR). The MAR fluids, like those from the EPR, appear to be in ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 558-560 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There are three major difficulties in interpreting the isotope composition of tree ring cellulose. ( 1 ) Organic matter is isotopi-cally inhomogeneous4' . (2) Complex biological, biochemical and hydrological processes take place during the growth of a tree7'12'15. (3) Isotope variations in ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 7 (1981), S. 61-64 
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Serum protein binding of methotrexate was studied in 14 patients with various forms of malignant disease and in eight age- and sex-matched subjects (control group) attending outpatient clinics for various clinical conditions. 2. Protein binding was determined by continuous ultrafiltration and methotrexate concentrations by double-antibody radioimmunoassay. 3. Protein binding of the drug is critically dependent on albumin concentration, as shown by results in individual subjects and a significant regression of methotrexate binding on albumin concentration. Moreover, at high methotrexate concentrations drug binding becomes non-linear, resulting in disproportional elevation of free methotrexate levels. Both these findings have important implications for the treatment of hypoalbuminaemic patients. 4. Two classes of binding sites were observed in both groups of patients, viz a high-affinity, low-capacity group and a low-affinity group with higher capacity. 5. No significant difference was found between patient and control groups either in the percent bound drug or in the binding parameters. 6. In conclusion, while there appear to be no factors specific to malignant disease which perturb methotrexate's protein binding, it may be important to determine the extent of drug binding before methotrexate can be used judiciously, particularly when total drug level is related to likely toxicity and in the design of an appropriate folinic acid rescue regimen after high-dose therapy.
    Type of Medium: Electronic Resource
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