ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The influence of nearly all known physiological isoprene-like carboxylic acids with 5 and 6 carbon atoms on the incorporation of [1-14C]-acetate into substances precipitated by digitonine was investigated by means of liver homogenates in buffers with various supplements.β,δ-Dihydroxy-β-methylvaleric acid and β-hydroxy- β-methylglutaric acid appear to be the most closely related to the hypothetical isoprene unit; isovaleric acid, β, β-dimethylacrylic acid and β-hydroxyβ isovaleric acid appear to lie on a by-path leading probably via β-hydroxy-β-methylglutaric acid to cholesterol. Trans- and cis-β-methyl- glutaconic acid do not seem either to be necessary intermediates in cholesterol biosynthesis. β-Methyl-crotylaldehyde, β-methyl-crotyl- alcohol and isomylalcohol considerably inhibited the incorporation of acetate; however, it was uncertain whether this was due to a true inhibition or whether it indicates a metabolic pathway from isovaleric acid and β, β-dimethylacrylic acid to cholesterol which does not proceed via β-hydroxy-β-methylglutaric acid.
Additional Material:
7 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19570400732
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