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  • 1
    Electronic Resource
    Electronic Resource
    LACK OF EFFECT OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR ON THE RAT AORTA OR HUMAN SAPHENOUS VEIN (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 17 (1990), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. In order to assess whether the observed hypotensive response in some patients given human granulocyte-macrophage colony stimulating factor (GM-CSF) is caused by a direct vascular effect of the GM-CSF, the effects of mouse and human GM-CSF were examined in rat aortic rings and human saphenous veins respectively.2. No effects of GM-CSF were observed, either in the presence or absence of endothelium, on responses to the α-adrenoceptor agonist phenylephrine.3. These data suggest that GM-CSF does not have direct effects on either vascular endothelium or smooth muscle, and that a direct vascular effect of GM-CSF is not the explanation for the observed clinical response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1990.tb01281.x
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of insulin-like growth factor II by a gastric carcinoma associated with hypoglycaemia (1994)
    Springer
    Virchows Archiv 424 (1994), S. 449-452 
    Details
    ISSN: 1432-2307
    Keywords: Insulin-like growth factor II ; Hypoglycaemia ; Gastric cancer ; Non-islet cell tumour hypoglycaemia ; Insulin receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A gastric cancer with liver metastases was associated with low morning levels of plasma glucose (24 mg/dl), insulin (〈2.5 μU/ml) and growth hormone (0.23 ng/ml). Primary and metastatic tumour tissue stained positively with anti-insulin-like growth factor II(IGF-II) monoclonal antibody. Western immunoblot analysis revealed a high molecular weight IGF-II in the serum: 15 kDa (normal: 7.5 kDa). Postmortem reverse transcription polymerase chain reaction on mRNA from both sites revealed 471 base pairs size cDNA encoding prepro-IGF-II. These results suggest that the gastric carcinoma encoded, expressed, and secreted IGF-II, probably causing the extrapancreatic tumour hypoglycaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00190569
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    Paper (German National Licenses)
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