ISSN:
1420-9071
Keywords:
Antihistamine
;
H1-receptor
;
feeding elicitation
;
α-fluoromethylhistidine
;
hypothalamic neuronal histamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Histamine antagonists were infused into the third ventricle of the cerebrum in rats. All the H1-, but none of the H2-antagonists tested, induced initial feeding during the early portion of the light phase when histamine level was highest. No periprandial drinking was observed. Ambulation increased during feeding. The effect on feeding was attenuated when brain histamine was normally low during the early portion of the dark phase, or was decreased by α-fluoromethylhistidine. Hypothalamic neuronal histamine may suppress food intake through H1-receptors, and diurnal fluctuations of food intake may mirror neuronal histamine levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01941710
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