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Digitale Medien

Degeneration of retinal neuroblasts by chinoform-ferric chelate (1982)

Ohtsuka, K. ; Ohishi, N. ; Eguchi, G. ; [weitere]

Springer

Cellular and molecular life sciences 38 (1982), S. 120-122

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ISSN: 1420-9071

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The possible mechanism of neuropathic effect of chinoform was investigated using cultured retinal neuroblasts from chick embryos. Retinal neuroblasts completely degenerated by chinoform-ferric chelate within a day. This change, however, was not observed with free chinoform or ferric ion.a-Tocopherol had a potent protective effect on the toxicity of the chelate. From these results, it was concluded that the lipid peroxidation due to ferric ion chelated with chinoform incorporated into the membrane of nerve tissues is the most important step in induction of the neuropathy.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01944564

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Digitale Medien

Amygdalar inputs to ADH-secreting supraoptic neurones in rats (1982)

Hamamura, M. ; Shibuki, K. ; Yagi, K.

Springer

Experimental brain research 48 (1982), S. 420-428

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ISSN: 1432-1106

Schlagwort(e): ADH-neurone ; Amygdala ; Rat ; Supraoptic nucleus

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Effects of amygdala stimulation on the discharge activity of antidromically identified supraoptic neurosecretory neurones were studied in male rats anaesthetized with urethane. Stimulation of the medial and the basal amygdala produced excitation or inhibition of discharge activity both in phasically firing (“phasic”) and in continuously firing (”continuous”) neurones. More “phasic” neurones were excited than were inhibited after medial amygdala stimulation. On the other hand, fewer “continuous” neurones were excited by stimulation of the either amygdala area than were inhibited. This difference of responsiveness between “phasic” and “continuous” neurones is statistically significant. Synaptic inputs to supraoptic neurosecretory neurones after amygdala stimulation were also observed in rats with a lesion of the stria terminalis. Supraoptic nucleus stimulation activated antidromically 14 of the 336 amygdala neurones tested. Since “phasic” neurones have been identified as ADH-secreting neurones, it is concluded that ADH-secreting neurones in the rat supraoptic nucleus receive predominantly excitatory synaptic inputs from the medial amygdala and these amygdalar synaptic inputs are mediated by pathways which are at least in part monosynaptic and are not included in the stria terminalis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00238618

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