ISSN:
1432-1106
Keywords:
Myelin deficiency
;
Mutant mice (msd)
;
Sulphatide synthesis
;
Cerebroside sulphotransferase
;
Developmental changes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary 1. The activity of the sulphotransferase involved in the synthesis of sulphatides, 3′-phosphoadenosine-5′-phosphosulphate cerebroside sulphotransferase (PAPS-CST), was determined in the developing CNS of the myelin synthesis deficiency mutant mouse (msd) and compared to that in control animals. There was a decrease of the PAPS-CST activity in msd mouse in the period from 8 to 26 days. The developmental curve of PAPS-CST activity in msd mice brains essentially paralleled that in normal animals, with a maximum at about 19 days. 2. Basic enzyme properties, such as Km, optimum pH, and heat inactivation, were not affected by the mutation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00238532
Permalink
