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  • 1
    Electronic Resource
    Electronic Resource
    Stimulation by hCRF of C-peptide release in type 2 diabetics during concomitant opioid receptor blockade (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 175-180 
    Details
    ISSN: 1432-1440
    Keywords: Human corticotropin-releasing factor (hCRF) ; C-peptide ; Naloxone ; Opioid receptor blockade ; Type 2 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of synthetic human corticotropin-releasing factor (hCRF, 2 µg/kg body weight) during simultaneous application of the opioid antagonist naloxone (1.6 mg i.v. bolus, followed by an infusion at a rate of 1.2 mg/h) produced a significant increase in plasma C-peptide levels of six male Type 2 diabetic patients which even exceeded the postprandial values. This stimulatory effect of hCRF/naloxone on plasma C-peptide was less pronounced in six healthy men. hCRF alone did not provoke any reaction of plasma C-peptide in either group. The possibility of a paracrine, CRF-dependent mechanism in pancreatic islets which somehow involves inhibitory opioid receptors is preferentially discussed. Such a mechanism may underlie the stimulatory action of hCRF/naloxone on B cells and would explain the absent reaction of peripheral venous plasma C-peptide to hCRF alone as well as the amplifying effect of simultaneous opioid receptor blockade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727787
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Potentiation of the hCRF-induced release of ACTH in man by an opioid antagonist (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 453-457 
    Details
    ISSN: 1432-1440
    Keywords: Human corticotropin-releasing factor (hCRF) ; ACTH ; Cortisol ; Naloxone ; Opioid receptor blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of synthetic human corticotropin-releasing factor (hCRF; 2 µg/kg body weight) to six normal male subjects produced a significant rise in plasma ACTH, followed by an increase in circulating cortisol. Simultaneous treatment with the opioid antagonist naloxone (1.6 mg i.v. bolus, followed by an infusion at a rate of 1.2 mg/h) significantly potentiated the hCRF-induced rise in ACTH and enhanced the cortisol response to hCRF. It is suggested that naloxone acts by antagonizing an inhibitory ultra-short-loop feedback effect of coreleased β-endorphin on pituitary corticotrophs, thereby amplifying the net effect of hCRF, i.e., the release of ACTH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712837
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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