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  • 1
    Electronic Resource
    Electronic Resource
    Cell-mediated cytotoxic islet cell surface antibodies to human pancreatic beta cells (1984)
    Springer
    Diabetologia 26 (1984), S. 30-33 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; islet cell surface antibodies ; cytotoxic antibodies ; antibody-dependent cell-mediated cytotoxcity ; human pancreatic B cells ; islet cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera containing islet cell surface antibodies show a complement-dependent cytotoxic reaction against islet cells, but it has not yet been clarified whether islet cell surface antibodies exhibit cell-mediated cytotoxicity to these cells. By 51Cr release assay we investigated whether islet cell surface antibodies showed a cytotoxic reaction to human pancreatic B cells (JHPI-1 clone) in the presence of normal human lymphocytes. The sera from 14 islet cell surface antibody-positive, 16 islet cell surface antibody-negative Type 1 (insulin-dependent) diabetic patients and 18 islet cell surface antibody-negative healthy subjects were studied. Four sera containing islet cell surface antibodies showed specific cytotoxicity above the mean +3SD value of healthy subjects, and the mean specific cytotoxicity of islet cell surface antibody-positive sera differed significantly from that of both islet cell surface antibody-negative groups. These results suggest that this cell-mediated cytotoxic mechanism may play an important role in the pathogenesis of Type 1 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252259
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Immunological aspect of non-obese diabetic mice: immune islet cell-killing mechanism and cell-mediated immunity (1984)
    Springer
    Diabetologia 27 (1984), S. 121-123 
    Details
    ISSN: 1432-0428
    Keywords: Non-obese diabetic mice ; cell-mediated cytotoxicity ; islet cells ; natural killer activity ; antibody-dependent cell-mediated cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The non-obese diabetic mouse is thought to be one of the best available animal models for human Type 1 (insulin-dependent) diabetes. By 51Cr release assay we investigated cell-mediated cytotoxicity to the islet cells of Balb/C mice, natural killer activity, and antibody-dependent cell-mediated cytotoxicity activity of spleen lymphocytes from pre-diabetic non-obese diabetic mice. The cell-mediated cytotoxicity to islet cells of non-obese diabetic mice was significantly higher than that of control ICR mice. In contrast, natural killer and antibody-dependent cell-mediated cytotoxicity activities of the spleen cells from the non-obese diabetic mice were significantly lower than those of ICR mice spleen cells. These results suggest that lymphocytes from non-obese diabetic mice were sensitized to the antigen of islet cells and that the non-specific cellular immunity of non-obese mice was reduced. They suggest also that this immune islet cell-killing mechanism may play an important role in the pathogenesis of diabetes in non-obese diabetic mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275666
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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