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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a double-blind randomized parallel-group study, six investigators enrolled 43 subjects to study the prophylactic effect of 10 mg cetirizine b.i.d. on grass pollen-induced asthma. The control group received 60 mg b.i.d. terfenadine, given to avoid withdrawals from the trial because of hay fever symptoms. Subjects were included in the study between the appearance of the first symptoms of hay fever and those of pollen-induced asthma. The hay fever and asthma symptoms, visual analogue scores (VAS), FEV1 and self-assessment data on complaints, salvage treatment and peak-flow values were statistically analysed. Both treatments were well tolerated, with a low and similar incidence of side-effects. During the last 3 weeks of treatment, six (32%) of the 19 subjects on cetirizine who were evaluable for efficacy remained free of asthma complaints, and another two (10%) had only a single minor attack. None had a grade 3 (incapacitating) attack. Conversely, only one (5%) of the 20 evaluable subjects on terfenadine remained complaint free, and all others (95%) had multiple attacks, which incapacitated three (15%) of them. Nasal obstruction, dyspnoea, morning peak flow, consumption of β2-mimetics and an efficacy index on asthma, combining complaints and rescue drug consumption, were significantly better on cetirizine (P 〈 0·05). It is concluded that cetirizine is able to prevent the exacerbation of asthma induced by grass pollen.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0009-8981
    Keywords: Antidiuretic hormone ; Brattleboro rat ; Diabetes insipidus ; PGE"2-9-ketoreductase ; Prostaglandin E"2 ; Prostaglandin F"2α
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mechanisms of Ageing and Development 35 (1986), S. 145-160 
    ISSN: 0047-6374
    Keywords: Aging ; Cartilages ; Mouse
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 53 (1962), S. 28-33 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Zusammenfassung Die Spezifität des ADH-Verfahrens zum Nachweis von Äthylalkohol wird durch Untersuchung von 14 verschiedenen Alkoholen geprüft und auf die sich daraus ergebenden forensischen Gesichtspunkte hingewiesen.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 25 (1969), S. 978-980 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Chez l'embryon de poulet femelle nous avons comparé à l'aide de la technique cytophotométrique de Lison la teneur en ADN des cellules germinales à noyau réticulé à celle des cellules au stade leptotène. Comme pendant la phase S d'un cycle cellulaire régulier, la quantité de DNA au cours du stade préleptotène, semble au moins doubler. Néanmoins nos résultats ne permettent pas d'affirmer ou d'exclure la possibilité d'une synthèse de DNA supplémentaire d'autre origine.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 52 (1962), S. 431-437 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Résumé A l'occasion de deux expertises sérologiques de paternité, l'effet de dosage a permis de faire la distinction entre les génotypes Cw/C et Cw/Cw.
    Notes: Zusammenfassung Im Rahmen von zwei serologischen Vaterschaftsuntersuchungen wurde durch Darstellung eines Dosis-Effektes zwischen den Genotypen Cw/C und Cw/Cw unterschieden.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 1024-1028 
    ISSN: 1432-1440
    Keywords: Glomerular prostanoid ; PGE2 ; PGI2 ; TxB2 ; Glomerular filtration rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is generally accepted that the main action of glomerular prostanoids (GPs) on glomerular filtration rate (GFR) is to modulate the activity of different vasoconstrictors, specially in states of renal hypoperfusion. However it was also suggested that GPs may directly affect GFR. The present study was focused on this last hypothesis, in different experimental models, in rats. In adriamycin induced acute renal failure, the transient decrease of GFR is associated with higher levels of thromboxane B2. Later on, when GFR returns to normal, vasodilator prostaglandins synthesis was also increased. In captopril induced renal failure in Na depleted rats (where GPs synthesis remained normal), stimulation of PGE2 and PGI2 production by K and NaCl was associated with a significant improvement of GFR. Furthermore, the increase in GFR induce by NaCl was prevented by inhibition of prostaglandin synthesis. Infusion of atrial natriuretic peptide in euvolemic rats induce a marked elevation both of GFR and PGE2 synthesis. It was abolished by previous administration of prostaglandin synthesis inhibitor. In conclusion, glomerular prostanoids may influence GFR, either directly, or as mediator or modulator of other vasoactive hormones.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Law and Psychiatry 4 (1981), S. 327-344 
    ISSN: 0160-2527
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology , Law
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 8 (1962), S. 294-296 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Blood from 80 alcoholics, most of whom showed bilirubinaemia, was examined. The 3 types of haptoglobin could definitely be determined in all cases. If there is difficulty in determining the type, the serum should be concentrated.
    Abstract: Résumé Ont été examinés 80 échantillons de sang d'alcooliques qui présentaient pour la plupart une hyperbilirubinémie. Les 3 types d'haptoglobine ont pu être établis dans tous les cas. Lorsque la détermination s'est avérée difficile, un examen de contrôle a été pratiqué aprés concentration du sérum.
    Notes: Zusammenfassung Es wurden 80 Blute von Alkoholikern, die zum überwiegenden Teil eine Hyperbilirubinämie zeigten, untersucht. In allen Fällen waren die 3 Haptoglobintypen einwandfrei zu bestimmen. Bei schlecht diagnostizierbaren Typen sollte eine Kontrolluntersuchung mit eingeengtem Serum durchgeführt werden.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 8 (1962), S. 334-338 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 100 specimens of cadaver blood (a variety of causes of death) have been examined by zone electrophoresis. In 73 cases the haptoglobin type could be definitely determined. In non-haemolytic sera it was possible to determine the haptoglobin type, but the great majority of the haemolytic sera could also be classified. In all cases of haemolytic serum in which it was not possible to estimate haptoglobin, attempts were made to raise the serum level of haptoglobin by concentration. This enabled us to determine the haptoglobin picture in a number of cases. The haptoglobin type could not be determined in 6 haemolytic sera and also in all decomposed blood from which serum was not expressed. The investigation appeared to be interfered with by changes in the serum proteins in the region of the alpha globulin fraction and by increase of haemoglobin in the beta globulin fraction. The causes of death and the time of death did not appear to affect haptoglobin estimation in our cases.
    Abstract: Résumé Des échantillons de sang prélevés après la mort dans 100 cas divers ont été soumis à une électrophorèse de zone. Le type d'haptoglobine a pu être établi dans 73 cas. L'analyse s'est effectuée sans difficulté pour tous les sérums non hémolytiques et pour 32 des 45 sérums hémolytiques. Pour les 13 sérums hémolytiques restants, il tut cependant possible d'obtenir une détermination dans 7 cas en augmentant la concentration sérique (dessication à froid et reprise en eau distillée). Dans 6 cas de sérum hémolytique et dans tous les cas où l'altération cadavérique ne permettait plus d'obtenir du sérum, le type d'haptoglobine n'a pas pu être établi. L'analyse a été manifestement perturbée par les modifications dans la fraction globulinique alpha et par l'augmentation de l'hémoglobine dans la fraction beta-globulinique. Dans la limite des cas examinés, la cause de mort ne semble pas avoir eu d'influence sur la détermination de l'haptoglobine, non plus que le temps écoulé entre le décès et le moment de l'analyse.
    Notes: Zusammenfassung Es wurden Blutproben von 100 Leichen mit verschiedenen Todesursachen zonenelektrophoretisch untersucht. In 73 Fällen ließen sich die Haptoglobintypen einwandfrei bestimmen. In nicht-hämolytischen Seren war der Haptoglobintyp in jedem Fall einwandfrei zu ermitteln. Der größte Anteil der hämolytischen Seren ergab noch klare Haptoglobinbilder. In allen Fällen hämolytischer Seren, wo eine Haptoglobin-Bestimmung nicht mehr möglich erschien, wurde versucht, die Haptoglobin-Serumkonzentration durch Einengung zu erhöhen. Dadurch waren in weiteren Fällen noch einwandfreie Haptoglobinbilder zu erhalten. Bei 6 hämolytischen Seren und bei allen faulen, kein Serum mehr absetzenden Bluten konnte der Haptoglobintyp nicht mehr ermittelt werden. Die Untersuchung war offensichtlich durch Serumprotein-Veränderungen im Bereich der Alpha-Globulin-Fraktion und durch Hämoglobin-Anreicherung in der Beta-Globulin-Fraktion empfindlich gestört. Die Todesursachen und die von uns untersuchten Todeszeiten schienen auf die Haptoglobin-Bestimmung keinerlei Einfluß genommen zu haben.
    Type of Medium: Electronic Resource
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