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  • 1
    ISSN: 1432-0428
    Keywords: Glycosylated haemoglobin ; home blood glucose monitoring ; diabetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serial capillary blood glucose levels from insulin treated patients were recorded over 24 hour periods at fortnightly intervals for three months. Total glycosylated haemoglobin as % of HbA was measured at the end of this period by the Flückiger method, and % HbA1 by column chromatography. There were highly significant correlations between mean blood glucose levels over the three months and % HbA1 (r=0.93, 95% confidence limits 0.84–0.98), and with total glycosylated haemoglobin (r=0.88, 95% confidence limits 0.75–0.94). There was also a good correlation between results obtained by the two methods (r=0.81, p〈0.0001). There were less strong correlations between % HbA1 and blood glucose levels during each of the three months before the estimation, with percentage of glucose levels greater than 10 mmol/l and with mean fasting blood glucose. These data support the hypothesis that % HbA1 and total glycosylated haemoglobin are satisfactory measurements of short term diabetic control.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 5 (1986), S. 513-517 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ketoconazole pharmacokinetics were determined in nine adults with haematological malignancy after one week on a 200 mg daily dose and later after one week on a 400 mg daily dose. The area under the serum concentration time curve (AUC) reached 12.3 ± 7.7 mg/l.h (mean ± S.D.) on the 200 mg dose and increased to 23.0 ± 18.2 mg/l.h on the 400 mg dose (p 〈 0.05). The half-life of ketoconazole was 3.1 + 1.9 h on the 200 mg dose and 3.5 ± 1.7 h on the 400 mg dose. Peak concentrations were 3.2 ±1.8 mg/l and 4.6 ± 3.2 mg/l on the 200 mg and 400 mg doses, respectively. Trough ketoconazole concentrations were undetectable 24 h after either dose. There was no correlation between the leucocyte count and any pharmacokinetic parameter for ketoconazole. Variation in AUC was 20-fold on the 200 mg daily dose and 8-fold on the 400 mg per day regimen. Measurement of serum levels during ketoconazole treatment appears necessary in view of the unpredictable concentrations achieved. Once-a-day dosage regimens of ketoconazole in immunocompromised patients may be inappropriate. Future clinical trials should adopt a two or three times a day dosing regimen, as this may confer a pharmacokinetic and therapeutic advantage.
    Type of Medium: Electronic Resource
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