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  • 1
    Digitale Medien
    Digitale Medien
    Haloperidol and lithium blocking of the mood response to intravenous methylphenidate (1978)
    Springer
    Psychopharmacology 57 (1978), S. 83-87 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Methylphenidate ; Haloperidol ; Lithium ; Euphoria ; Manic-depressive ; Dopamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ten euthymic manic-depressive patients with therapeutic plasma lithium levels were each given two i.v. infusions of 30 mg of methylphenidate. The infusions were separated by at least 3 days. Before one infusion each patient was given 5 mg of haloperidol i.v. and before the other infusion each was given an identical volume of saline. A psychiatric observer was blind to the nature of the pretreatment and the order of pretreatment was randomized. Saline pretreated patients showed marked activation and euphoriant responses despite therapeutic lithium levels. Haloperidol pretreatment reduced this response in three patients and eliminated the euphoriant and activating response in the remaining seven patients. These results agree with the existence of a dopaminergic step in the induction of methylphenidate-induced activation and euphoria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426962
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  • 2
    Digitale Medien
    Digitale Medien
    The effect of haloperidol on epinephrine-stimulated adenylate cyclase in humans (1976)
    Springer
    Psychopharmacology 49 (1976), S. 215-217 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Lithium ; Haloperidol ; Epinephrine ; Adenylate cyclase ; Mania
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Administration of epinephrine in man has been shown previously to lead to a rise in plasma cyclic AMP levels by activation of the β-adrenergic-stimulated adenylate cyclase. Therapeutic doses of lithium in humans block the epinephrine-induced rise in plasma cyclic AMP levels, suggesting that lithium inhibits β-adrenergic adenylate cyclase. In contrast, ten subjects receiving haloperidol, a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals. These findings are discussed in relation to the possible pharmacological mechanisms of action of lithium and haloperidol in the control of mania.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00427293
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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