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Digitale Medien

Fluctuations in circulating cell numbers following chemotherapy or bone marrow transplant (1994)

Schwegler, Helmut ; Mackey, Michael C.

Springer

Journal of mathematical biology 32 (1994), S. 761-770

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Details

ISSN: 1432-1416

Schlagwort(e): Fluctuations ; Stochastic PDEs ; Blood cell maturation ; Chemotherapy ; Bone marrow transplant

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Mathematik

Notizen: Abstract We study the effect of noise on the behaviour of a dynamic cell population model in which cell replication and maturation take place simultaneously. We assume that the maximum proliferative potential ν fluctuates uniformly about a mean value of v, and show that a decrease in v and/or the input flux u in into the population can lead to an increase in the variance in the cellular efflux u f. We draw a qualitative correspondence between this behaviour and the commonly observed increase in the variance of circulating blood cell numbers following chemotherapy and radiotherapy, both of which lead to a decrease in v and u in , and bone marrow transplant which probably corresponds to a decrease in u in .

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00168796

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