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  • Clauberg-McPhail assay  (1)
  • Diels—Alder reaction  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Catalysis by lewis acids at high pressure as a method of involving hindered steroid dienophiles in the diels—Alder reaction (1992)
    Springer
    Russian chemical bulletin 41 (1992), S. 1253-1257 
    Details
    ISSN: 1573-9171
    Schlagwort(e): Lewis acid ; high pressure ; steroid enones and dienones ; Diels—Alder reaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The joint action of Lewis acids and high pressure permits the Diels—Alder reaction to be conducted with high yields with greatly sterically hindered steroid dienophiles, which are virtually unreactive under normal conditions. The [2 + 4]-cycloadditions of dienes to Δ16-20-, Δ1-3-, Δ1,4-3-, and Δ4,6-3-ketones proceed stereospecifically with the formation of one stereoisomer for each cycloadduct. The reactions of the steroid dienes studied give mixtures of two monocycloadducts at both double bonds of the steroid, with predominance of the adduct at the sterically less-hindered double bond (Δ1- and Δ6-). The method developed is a new method of producing various modified steroids with possible hormonal or antihormonal activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00864191
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Some derivatives of pregna-D6′-pentaranes as possible antagonists of progesterone (1995)
    Springer
    Russian chemical bulletin 44 (1995), S. 547-550 
    Details
    ISSN: 1573-9171
    Schlagwort(e): pentarane ; progestin ; Clauberg-McPhail assay ; antihormonal action ; progesterone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Some derivatives of progestins of the pregna-D6′-pentarane series have been obtained and examined for their possible hormonal and antihormonal activity in the Clauberg-McPhail assay as well as in the pregnancy maintenance test in ovariectomized rabbits. 16α, 17α-Cyclohexanoprogesterones of the 19-methyl and 19-nor series (1–4) saturated in ring A, which are inactive as progestins, exhibited a remarkable antiprogesterone effect. They decreased the McPhail index under combined administration with progesterone in a dose-dependable manner and completely inhibited the action of the latter in the pregnancy maintenance test.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00702407
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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