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Digitale Medien

Bound sulphadimidine residues in raw fermented sausage: release under acidic conditions and bioavailability in rats (1999)

Smit, L. A. ; Haagsma, N. ; Ruiter, A.

Springer

Zeitschrift für Lebensmittel-Untersuchung und -Forschung 208 (1999), S. 183-188

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Details

ISSN: 1431-4630

Schlagwort(e): Key words Sulphadimidine ; Fermented sausage ; Carbon-14-labelling ; Rat ; Bound residues

Quelle: Springer Online Journal Archives 1860-2000

Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Abstract Sulphadimidine (SDM), a drug frequently administered to pigs, is partially converted into other compounds by processing meat to produce raw, fermented sausage. With the aid of 14C-labelled SDM, evidence was obtained that part of the radioactive matter was covalently bound to the matrix. Part of these bound residues could be released in vitro by 4 M HCl at 21 °C or by 0.024 M HCl at 37 °C. Female rats were also able to release bound SDM residues and to excrete these in their urine, in amounts approaching those obtained by treatment with 4 M HCl. Both the parent compound and its main metabolite, N 4-acetyl-SDM, were observed in the urine of rats.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002170050399

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