Digitale Medien
Springer
Naunyn-Schmiedeberg's archives of pharmacology
293 (1976), S. 39-47
ISSN:
1432-1912
Schlagwort(e):
Cardiac glycosides
;
Membranes
;
Lecithin
;
Phase separation
;
Spin-label
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The binding of digitoxigenin to lecithin model membranes was investigated by application of electron spin- and nuclear magnetic resonance methods. A digitoxigenin spin-label derivative was found to bind specifically to the pseudohexagonal rigid lattice of lecithin membranes. The binding is accomplished by some of the structural features which are required for the biological activity of cardiac glycosides. Digitoxigenin has a procooperative effect on dipalmitoyl-lecithin membranes. The induction of lipid phase separation is discussed as a hypothetic molecular mechanism of action of cardiac glycosides on biological membranes.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00498869
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