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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Pharmaceutical research 3 (1986), S. 12-22 
    ISSN: 1573-904X
    Schlagwort(e): powder compression ; compression equations ; compactibility ; compressibility ; compression equations ; compact hardness tests
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract In spite of the widespread use of tablets, the theoretical understanding of the tableting process has been limited. During the last decades considerable research has been done in the field of powder technology and compaction. A survey of the literature and compression equations reveals many studies on the characterization of powder properties, most of which relate to volume reduction under pressure, i.e., to the compressibility of the powder bed. For practical purposes, however, it is also important to know the compactibility of a powder bed, i.e., the ability of a powdered material to be compressed into a compact of specified strength. This strength has to be defined, e.g., as radial tensile strength or deformation hardness. Thus the first part of this review comprises the theory of powder compression of individual substances, compression parameters, compression equations, and mechanical properties of compacts, including compact strength tests and compact hardness tests.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Pharmaceutical research 3 (1986), S. 65-74 
    ISSN: 1573-904X
    Schlagwort(e): compression ; compressibility ; compactibility ; binary powder mixtures ; additivity rules ; strength of a compact ; sticking ; capping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Although tablet formulations are multicomponent systems, there have been only a few studies on the compression of binary or ternary powder mixtures. Physical interactions between the individual components may influence important biopharmaceutical properties of the compact, e.g., disintegration time and dissolution rate of the active ingredient. In the second part of this review paper the importance of these physical interactions is emphasized. The investigations are limited to the strength of the compact. An attempt is made to deduce additivity rules for the material-specific compressibility and compactibility parameters. Such additivity rules are of special importance, as they may allow the prediction of tablet properties at the formulation test. The final section is devoted to problems in compression, i.e., sticking and capping.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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