ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Chicken lymphoid organs were examined for IgGFc and complement receptors (FcR/CR) by immune adherence on frozen tissue sections. Indicator systems were sheep erythrocytes (E) coated with chicken anti-E IgG (Each). E coated with rabbit anti-E IgG (EArab) and normal chicken serum (EAC), and FITC-labelled zymosan particles coated with chicken serum (ZyC). In the spleen, FcR and CR activity was confined to B-dependent areas, i.e. the periellipsoidal sheaths and germinal centres and the red pulp. No FcR were found in the thymic or bursal lymphoid tissue, but CR activity was observed in the medulla of bursal follicles. Chicken and turkey IgG, chicken IgGFc, and bovine serum albumin (BSA)-chicken anti-BSA complexes inhibited binding of EAch. No inhibition was obtained with chicken IgGF(ab′)2. IgM or albumin, or with BSA-rabbit anti-BSA complexes and human or rabbit IgG. E did not adhere to the sections, nor did EArab, EArab incubated with heat-inactivated chicken serum, or EAC complexes prepared with EArab and guineapig complement. The data suggest that chicken B lymphocytes and macrophages have receptors for avian IgGFc and C which can be demonstrated in tissue sections.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1981.tb00194.x
Permalink