Digitale Medien
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Medicine
53 (2002), S. 595-614
ISSN:
0066-4219
Quelle:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Thema:
Medizin
Notizen:
Abstract The discovery and development of more than a dozen drugs in the past 15 years for the treatment of AIDS offer an excellent example of progress in the field of rational drug design. At this time, the principal targets are reverse transcriptase and protease, enzymes encoded by the human immunodeficiency virus. The introduction of protease inhibitors, in particular, has drastically decreased the mortality and morbidity associated with AIDS. This review presents the methods used to develop such drugs and discusses the remaining problems, such as the rapid emergence of drug resistance.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1146/annurev.med.53.052901.131947
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