ISSN:
1432-1335
Keywords:
Key words Cell migration
;
Metastasis formation
;
Cell-matrix interaction
;
Cytoskeleton
;
Chemokine
;
AbbreviationsEGF epidermal growth factor
;
FAK focal adhesion kinase
;
fMLP formyl-methionyl-leucyl-phenylalanine
;
JAK janus kinase
;
MARCKS myristoylated, alanine-rich C kinase substrate
;
MTOC microtubule organizing center
;
PDGF platelet-derived growth factor
;
PKA protein kinase A
;
PKC protein kinase C
;
ROCK
;
Rho-associated coiled-coil forming kinase
;
PLC phospholipase C
;
PTK protein tyrosine kinase
;
RANTES regulated upon activation normal T cell expressed and secreted
;
RTK receptor tyrosine kinase
;
STAT signal transducers and activators for transcription
;
ZAP-70 zeta-chain-associated protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Increasing evidence has shown that the molecular regulation of active cell migration of slow-moving cells, e.g., tumor cells and fibroblasts, is different from fast-moving leukocytes, e.g., T lymphocytes and neutrophil granulocytes. Slow-moving cells develop focal adhesions as a crucial regulatory element during migration. These focal adhesions connect the extracellular matrix to the intracellular actin- and tubulin-cytoskeleton via integrins and enzymatically active proteins. Beside matrix-binding integrins, ligands of receptor tyrosine kinases and heterotrimeric G protein-coupled serpentine receptors initiate migration of slow-moving cells. Focal adhesions are not found in T lymphocytes and neutrophil granulocytes moving within three-dimensional matrices. In T lymphocytes, the T cell receptor is supposed to have a key regulatory function not only in antigen recognition, cell activation, and proliferation but also in cell migration. Regulatory molecules as well as the cytoskeleton are connected to the T cell receptor. The T cell receptor functionally combines elements of receptor tyrosine kinase signaling and of focal adhesions. In neutrophil granulocytes no multi-protein complexes regulating migration have been identified so far. Most potent activators of migration of neutrophil granulocytes, as those of T lymphocytes, are chemokines binding to heterotrimeric G protein-coupled serpentine receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004320000143
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