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  • 1
    Electronic Resource
    Electronic Resource
    Electroconcentration by using countercurrent due to pressurized flow and electrophoretic mobility (1993)
    s.l. : American Chemical Society
    Analytical chemistry 65 (1993), S. 2882-2886 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00068a027
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  • 2
    Electronic Resource
    Electronic Resource
    NAK is an IκB kinase-activating kinase (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 404 (2000), S. 778-782 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Phosphorylation of IκB by the IκB kinase (IKK) complex is a critical step leading to IκB degradation and activation of transcription factor NF-κB. The IKK complex contains two catalytic subunits, IKKα and IKKβ, the latter being indispensable for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35008109
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of tracheal mucosal blood flow during an extended radical operation for esophageal carcinoma: Clinical and experimental studies (1994)
    Springer
    Surgery today 24 (1994), S. 585-590 
    Details
    ISSN: 1436-2813
    Keywords: esophageal carcinoma ; lymph node dissection ; tracheal mucosal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using the hydrogen gas clearance method, a platetype probe was attached to the surface of the cuff of an endotracheal tube in order to measure the ischemic changes in the tracheal mucosa produced by peritracheal lymph node dissection. In eight human subjects with intrathoracic esophageal carcinoma, the tracheal mucosal blood flow was 40.1 ml/100 g per minute after they had undergone a right thoracotomy and then decreased to 13.0 ml/100 g per minute after they had further received an extended radical operation preserving the right bronchial artery. No tracheal ulcers were seen. The same ischemic changes in the tracheal mucosa were also measured in dogs. The right bronchial artery contributes about one-third of the total blood flow to the trachea and this was thus calculated to be about 10-14 ml/100 g per minute.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01833720
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in liver blood flow after hepatectomy in conscious dogs (1996)
    Springer
    Surgery today 26 (1996), S. 688-693 
    Details
    ISSN: 1436-2813
    Keywords: liver blood flow ; hepatectomy ; concious dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatic circulation after hepatectomy was investigated in conscious dogs under fasting and feeding conditions. After a 40% hepatectomy, both the hepatic arterial and portal blood flow were measured simultaneously using ultrasonic transit time flowmeters. During fasting, the total hepatic blood flow (i.e., the sum of arterial and portal blood flow) changed in a biphasic pattern after hepatectomy. The first peak (517.9±42.7 ml/min; 130.1% of preoperative flow) was seen on the 1st postoperative day (POD) and the second peak (444.8±25.6 ml/min; 112.7% of preoperative flow) occurred on the 7th POD. The portal flow demonstrated the same biphasic changes as the total hepatic flow, although the hepatic arterial flow showed only the first peak. A heart rate analysis suggested that the first peak was probably due to hyperdynamic circulatory conditions, as has been previously reported. In addition, the existence of the second peak was established by the present study. The postprandial hepatic blood flow decreased during the first 2 weeks postoperatively, but exceeded the presurgical levels on PODs 21 and 28.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312085
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  • 5
    Electronic Resource
    Electronic Resource
    Recovery of portal blood flow after percutaneous transhepatic biliary drainage in patients with obstructive jaundice (1997)
    Springer
    Surgery today 27 (1997), S. 120-123 
    Details
    ISSN: 1436-2813
    Keywords: Doppler ; liver blood flow ; obstructive jaundice ; percutaneous transhepatic biliary drainage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using an ultrasonic Doppler system, we prospectively studied the changes in portal venous flow (PVF) following percutaneous transhepatic biliary drainage (PTBD) and evaluated the correlation between PVF and liver function in 10 patients with obstructive jaundice. The patients were divided into two groups according to their rate of decrease in serum bilirubin (“b”). Group A comprised 5 patients with a “b” of less than −0.1, while group B consisted of 5 patients who did not meet this criterion. The mean PVF increased following PTBD (P〈0.01). The increase in PVF was due to an increase in the maximum velocity of the portal vein (Vmax). The rate of increase in the Vmax in group A was significantly higher than that in group B on both the 7th and 14th postdrainage days (P〈0.05). The rate of increase in the Vmax correlated significantly with the rate of decrease in the serum bilirubin concentration (P〈0.01). Based on the above findings, we conclude that measuring the Vmax by Doppler ultrasonography is useful in evaluating the liver function in patients with obstructive jaundice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385899
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  • 6
    Electronic Resource
    Electronic Resource
    Multiple myeloma mimicking bone metastasis from breast cancer: Report of a case (1998)
    Springer
    Surgery today 28 (1998), S. 1304-1306 
    Details
    ISSN: 1436-2813
    Keywords: multiple myeloma ; metastatic breast cancer ; lytic bone lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 72-year-old woman with a history of early breast cancer suffered a fracture of the eighth thoracic vertebra resulting in paraplegia. Magnetic resonance imaging (MRI) showed spinal cord compression by a tumor between the ninth and tenth thoracic vertebrae. Local radiotherapy was begun under the diagnosis of metastatic breast cancer, but bone marrow aspiration and biopsy subsequently revealed plasma-cell proliferation rather than adenocarcinoma. This case report serves to demonstrate that clinicians should consider multiple myeloma as a cause of lytic bone lesions without extraskeletal metastases even in patients with a history of breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02482821
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  • 7
    Electronic Resource
    Electronic Resource
    Preoperative cholangiography of the caudate lobe: Surgical anatomy and staging for biliary carcinoma (1994)
    Springer
    Journal of hepato-biliary-pancreatic surgery 1 (1994), S. 385-389 
    Details
    ISSN: 1436-0691
    Keywords: Cholangiography ; Caudate lobe ; Bile duct carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The biliary branches of the caudate lobe (B1) join the right hepatic duct, the left hepatic duct, the confluence of these ducts, and/or the right posterior segmental bile duct. Therefore, in the preoperative staging of biliary tract carcinoma it is important to delineate the anatomy of B1 and the extent of cancer spread into B1. Tube cholangiography through percutaneous transhepatic biliary drainage or selective cholangiography by percutaneous transhepatic cholangioscopy enables us to obtain fine images of B1. We have developed cholangiography in the cephalad anterior oblique position to visualize B1 more clearly and distinctly. Four separate types of biliary branches are identified in the caudate lobe: (1) A duct running from the cranial portion of the right caudate lobe along the inferior vena cava to the hepatic hilus (B1r); (2) a duct from the cranial portion of the left caudate lobe to the hepatic hilus (B1ls); (3) a duct from the left lateral part of the left caudate lobe to the hepatic hilus (B1li); and (4) a duct from the caudate process to the hepatic hilus (B1c). The findings of the root of B1 in resected patients with biliary tract carcinoma were classified into four groups: not stenotic, short segmental stenosis, long segmental stenosis, and poorly imaged. A study of 64 branches of B1 in 42 resected patients with biliary tract cancer revealed carcinoma invasion in or near the root of B1 in all patients with poorly imaged or long segmental stenosis of B1, and in 33% of those with short segmental stenosis of B1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02391100
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  • 8
    Electronic Resource
    Electronic Resource
    Recurrent liver tumor with intrabiliary ductal growth after hepatectomy for metastatic rectal cancer: Case report (1995)
    Springer
    Journal of hepato-biliary-pancreatic surgery 2 (1995), S. 177-183 
    Details
    ISSN: 1436-0691
    Keywords: liver metastasis from colorectal cancer ; recurrence after hepatectomy ; intrabiliary ductal growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of recurrent tumor with intrabiliary ductal growth after hepatic resection for liver metastasis from rectal cancer is presented. The patient, a 55-year-old female, underwent subsegmentectomy of the anteroinferior and posteroinferior areas of the liver for metastatic liver cancer on August 29, 1988. Computed tomography in February 1990 showed dilatation of the intrahepatic bile duct in the right anterosuperior subsegment (B8), in which a filling defect was detected by cholangiography through a percutaneous transhepatic biliary drainage (PTBD) catheter. Percutaneous transhepatic cholangioscopy (PTCS) revealed a protruding lesion without tumor vessels. Cholangioscopic biopsy revealed dysplasia, but not adenocarcinoma. However, recurrent tumor originating in the resected margin of the remnant liver was suspected, and resection of the right lobe of the liver and partial resection of the duodenum were therefore performed. The resected specimen showed a tumor, 4 cm in diameter, in the previous resected margin, forming a protruding lesion with a rough surface (measuring 10×20 mm) in the B8 bile duct. This case suggested the possibility of cancer recurrence in the resected margin of the liver after hepatectomy for metastatic colorectal cancer, with intrabiliary ductal tumor growth showing segmental biliary dilatation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348746
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  • 9
    Electronic Resource
    Electronic Resource
    Hilar cholangiocarcinoma—surgical anatomy and curative resection (1995)
    Springer
    Journal of hepato-biliary-pancreatic surgery 2 (1995), S. 239-248 
    Details
    ISSN: 1436-0691
    Keywords: cholangiocarcinoma ; bile duct cancer ; hepatic hilus ; caudate lobe ; surgical anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have studied the surgical anatomy of the intrahepatic bile duct, hepatic hilus, and caudate lobe based on intraoperative findings and selective cholangiography of surgical patients and resected specimens, and have established the cholangiographic anatomy of the intrahepatic subsegmental bile duct. Thorough knowledge of the three-dimensional anatomy of the subsegmental bile duct, hepatic hilus, and caudate lobe is indispensable for curative surgery of hilar cholangiocarcinoma. We designed and actually performed 15 kinds of hepatic segmentectomies with caudate lobectomy and extrahepatic bile buct resection in 100 consecutive patients, with curative resection being possible in 82 patients. Postoperative survival after curative resection of hilar cholangiocarcinoma was better than expected, and the 5-year survival rates for all 82 patients with curative resection and for 55 patients with curative surgery without portal vein resection were 31% and 43%, respectively. Hepatic segmentectomy with caudate lobectomy and extrahepatic bile duct resection should be designed not only in accordance with the preoperative diagnosis of tumor extension into the intrahepatic bile ducts but also so that curative surgery for advanced hilar cholangiocarcinoma can be performed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02350905
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  • 10
    Electronic Resource
    Electronic Resource
    Pylorus-preserving pancreatoduodenectomy is applicable to patients with carcinoma of the head of the pancreas: Studies of lymph node metastasis and quality of life (1995)
    Springer
    Journal of hepato-biliary-pancreatic surgery 2 (1995), S. 150-155 
    Details
    ISSN: 1436-0691
    Keywords: pylorus-preserving pancreatoduodenectomy ; carcinoma of the head of the pancreas ; involvement of gastric lymph nodes ; quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Metastases to the regional lymph nodes of the stomach were studied in patients in whom carcinoma of the head of the pancreas had been resected (51 standard pancreatoduodenectomy and 26 total pancreatectomy). Involvement of gastric lymph nodes was rare (1.3%–3.9%), except of the subpyloric lymph nodes (9.1%). Carcinoma in the five patients with positive gastric lymph nodes, with the exception of the subpyloric nodes, was clinically far advanced: four of the five had liver metastasis or peritoneal dissemination. This suggests that, in terms of preservation of the regional gastric lymph nodes, only subpyloric node involvement has any significance with respect to surgical treatment of carcinoma of the head of the pancreas. There was no significant difference in survival rates after curative resection between standard pancreatoduodenectomy (n=44) and pylorus-preserving pancreatoduodenectomy (n=17). In the patients who underwent the pylorus-preserving pancreatoduodenectomy for various kinds of periampullary diseases (n=47), postoperative recovery of gastric and small bowel function was temporarily prolonged compared to that after shandard pancreatoduodenectomy (n=44). However, the former group were able to take significantly more calories 6 weeks after the operation. Our study indicates that the pylorus-preserving pancreatoduodenectomy with subpyloric lymph node dissection is applicable to the treatment of patients with carcinoma of the head of the pancreas from the viewpoints of both extent of operation and quality of life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348741
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