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  • Articles: DFG German National Licenses  (24)
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  • ZIB Catalog
  • Articles: DFG German National Licenses  (24)
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  • 2020-2023
  • 2010-2014
  • 2005-2009
  • 1990-1994  (24)
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  • 1
    Electronic Resource
    Electronic Resource
    The venous drainage of the pancreas (1994)
    Springer
    Surgical and radiologic anatomy 16 (1994), S. 37-45 
    Details
    ISSN: 1279-8517
    Keywords: Pancreas ; Pancreatic veins ; Duodenum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dans le but d'éclaircir certains aspects contradictoires de la description du drainage veineux du pancréas, une revue de la littérature et une recherche anatomique ont été effectuées. Cinquante blocs duodénopancréatiques ont été étudiés selon la technique d'injection-corrosion, desquels 45 ont été retenus pour l'étude du pancréas droit et 37 pour celle du pancréas gauche. Le drainage veineux du duodéno-pancréas est assuré suivant deux territoires: un postérosupérieur et un antéro-inférieur, le premier se drainant vers la v. porte et le deuxième dans la v.mésentérique supérieure. La charnière entre les deux est représentée par la v. pancréatico-duodénale inférieure et postérieure (PDIP). Quatre veines assurent le drainage duodéno-pancréatique: pancréatico-duodénale supérieure et antérieure (PDSA), pancréatico-duodénale inférieure et antérieure (PDIA), pancréatico-duodénale supérieure et postérieure (PDSP) et pancréatico-duodénale inférieure et postérieure (PDIP). La veine la plus importante de la face ventrale est la PDSA, celle de la face dorsale est la PDSP. Deux arcades, antérieure et postérieure, ont été retrouvées dans la plupart des cas. Le pancréas gauche se draine dans la v. splénique à travers plusieurs branches collatérales. D'autres veines participent au drainage veineux de l'isthme, du corps et de la queue du pancréas, dont la v. pancréatique inférieure ou transverse.
    Notes: Summary With the aim of clarifying certain contradictory aspects of the description of the venous drainage of the pancreas, a review of the literature and an anatomic study were carried out. Fifty duodeno-pancreatic blocks were studied by the injection-corrosion technique, of which 45 were available for study of the right pancreas and 37 for that of the left pancreas. The venous drainage of the duodeno-pancreas is effected via two territories: a posterosuperior and an anteroinferior, the former draining toward the portal v. and the second into the superior mesenteric v. The borderline between the two is represented by the inferior posterior pancreatico-duodenal (IPPD) v. Four veins ensure duodeno-pancreatic drainage: the superior anterior, inferior anterior, superior posterior and inferior posterior pancreatico-duodenal vv. (SAPD, IAPD, SPPD and IPPD). The major vein of the ventral aspect is the SAPD; that of the dorsal aspect is the SPPD. Two arches, anterior and posterior, were found in the majority of cases. The left pancreas drains into the splenic v. via several collateral branches. Other veins participate in the venous drainage of the isthmus, body and tail of the pancreas, including the inferior or transverse pancreatic v.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01627919
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  • 2
    Electronic Resource
    Electronic Resource
    An α-fetoprotein producing pancreatic cystadenocarcinoma (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 377-380 
    Details
    ISSN: 1432-1440
    Keywords: Mucinous cystadenocarcinoma ; Pancreas ; α-Fetoprotein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An autopsy case of an 83-year-old Japanese woman with pancreatic cancer with significantly elevated serum α-fetoprotein levels is reported. The pancreatic tumor was a mucinous cystadeno-carcinoma with multiple metastasis to the liver. The immunohistochemistry for α-fetoprotein revealed positive reactivity in the cytoplasm of cancer cells in the primary and liver metastatic lesions. The current case is the first reported in which mucinous cystadenocarcinoma of the pancreas produced α-fetoprotein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252831
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  • 3
    Electronic Resource
    Electronic Resource
    Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma (1994)
    Springer
    Virchows Archiv 424 (1994), S. 13-17 
    Details
    ISSN: 1432-2307
    Keywords: Pancreas ; Serous cystic tumours ; Microcystic adenoma ; Serous oligocystic ill-demarcated adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serous cystic tumours of the pancreas are uncommon and are usually classified as microcystic adenomas (MCA). As new types of serous cystic tumours of this organ have been reported we reviewed a series of 14 lesions and from macroscopic findings two groups were distinguished: ten tumours revealed the features of MCA, while four were clearly distinct from MCA. Grossly, the latter tumours showed only few cysts which were irregularly assembled in fibrous stroma. On the cut surface, there was neither a central stellate scar nor a circumscribed tumour border, features characterizing MCA. Microscopically, the cysts were lined by cuboidal, non-mucin-producing cells. Immunocytochemical staining for cytokeratins 7, 8, 18 and 19 revealed a ductal phenotype. All non-MCA were found in the head of the pancreas and three of them occurred in men. There were no tumour recurrences or signs of malignant transformation after resection (mean follow-up, 2.9 years). These results suggest that there are serous cystic tumours distinct from MCA which may represent another variant of the category of serous cystic adenomas of the pancreas. We propose the term serous oligocystic and ill-demarcated adenoma (SOIA) for these tumours. It is possible that the recently described macrocystic subtype of serous cystadenoma and SOIA are variants of the same tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197387
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  • 4
    Electronic Resource
    Electronic Resource
    Pancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats (1994)
    Springer
    Diabetologia 37 (1994), S. 994-999 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas ; growth factors ; gene expression ; beta cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The Reg/pancreatic stone protein (PSP) gene is postulated to be an important regulator of pancreatic beta-cell growth. To investigate this hypothesis, we analysed the expression of the Reg/PSP gene following a 90% pancreatectomy and after chronic glucose infusion, two well-defined models of pancreatic beta-cell growth. There was a rapid induction of the Reg/PSP gene in the remnant pancreas after a 90% pancreatectomy in rats during the period of marked growth of the exocrine and islet tissue. However, a similar rapid, but smaller, induction of the Reg/PSP gene was observed in sham-operated rats and in non-surgical control rats in which there was no enhanced pancreatic growth. Furthermore, there was no pancreatic Reg/PSP gene induction in a model of selective beta-cell growth, the chronic glucose-infused rat. Thus, it is unlikely that Reg/PSP is a beta-cell specific growth factor, even though the function of this important pancreatic gene is still unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400462
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  • 5
    Electronic Resource
    Electronic Resource
    Pancreatic castleman disease: CT findings (1994)
    Springer
    Abdominal imaging 19 (1994), S. 160-161 
    Details
    ISSN: 1432-0509
    Keywords: Pancreas ; Castleman disease ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Computed tomography findings in a case of pancreatic localization of Castleman disease are presented correlated with histological findings. This is the second observation in the literature of pancreatic involvement with an unusual histological form.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00203494
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  • 6
    Electronic Resource
    Electronic Resource
    MR imaging of annular pancreas (1994)
    Springer
    Abdominal imaging 19 (1994), S. 301-303 
    Details
    ISSN: 1432-0509
    Keywords: Pancreas ; abnormalities ; Pancreas ; MR and CT diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The appearance of annular pancreas on magnetic resonance (MR) images is described in a 14-year-old boy with pancreatitis and incomplete pancreas divisum. The presence of the coexisting abnormalities complicated the interpretation of an upper gastrointestinal series and computed tomographic (CT) study. MR imaging was useful as a problem-solving technique to supplement the conventional imaging tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198183
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  • 7
    Electronic Resource
    Electronic Resource
    A voltage-sensitive transient potassium current in mouse pancreatic acinar cells (1994)
    Springer
    Pflügers Archiv 428 (1994), S. 288-295 
    Details
    ISSN: 1432-2013
    Keywords: K+ current ; Pancreas ; Acinar cell ; Fluid secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe, for the first time, a potassium current in acutely isolated mouse pancreatic acinar cells. This current is activated by depolarization and has many of the characteristics of the fast transient potassium current of neurones where roles in shaping action potential duration and frequency have been proposed. Although acinar cells do not carry action potentials, our experiments indicate that the primary regulator of the current in these cells is the membrane potential. In whole-cell patch-clamped cells we demonstrate an outward current activated by depolarization. This current was transient and inactivated over the duration of the pulse (100–500 ms). The decay of the inactivation was adequately fitted by a single exponential. The time constant of decay, τ, at a membrane potential of +20 mV was 34±0.6 ms (mean±SEM,n=6) and decreased with more positive pulse potentials. The steady-state inactivation kinetics showed that depolarized holding potentials reduced the amplitude of the current observed with a half-maximal inactivation at a membrane potential of −40.6±0.33 mV (mean±SEM,n=5). These activation and inactivation characteristics were not affected by low intracellular calcium (10−10mol · 1−1) or by an increase in calcium (up to 180 nmol · 1−1). In addition we found no effect on the current of dibutyryl cyclic adenosine monophosphate (db-cAMP) or the agonist acetylcholine. The current was blocked by 4-aminopyridine (K d approximately 0.5 mmol · 1−1) but not affected by 10 mmol · 1−1 tetraethylammonium. Whole-cell patch-clamp experiments were also carried out on acutely isolated mouse lacrimal acinar cells. Depolarizing voltage-clamp steps elicited only a slowly activating outward current that was blocked by tetraethylammonium. We found no evidence for the fast transient outward current in the exocrine cells of the lacrimal gland. We postulate that the transient potassium current in the acinar cells of the mouse pancreas would act to hyperpolarize the cell and may play a role in fluid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00724509
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  • 8
    Electronic Resource
    Electronic Resource
    Assessment of the labelling index of cohorts of the pancreatic islet cell population in phenobarbitone-treated male rats using a double immunohistochemical technique for 5-bromo-2′-deoxyuridine and pancreatic hormones (1994)
    Springer
    Archives of toxicology 69 (1994), S. 52-58 
    Details
    ISSN: 1432-0738
    Keywords: Key words Cell proliferation ; Pancreas ; 5-Bromo-2′-deoxyuridine (BrdU) ; Immunohistochemistry ; Hormones ; Insulin ; Glucagon ; Somatostatin ; Phenobarbitone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A previous study demonstrated that administration of phenobarbitone to male AP Wistar rats for up to 7 days caused alterations in labelling indices (LIs) in several different tissues (including a reduction of the endocrine pancreas population LI) as determined by immunohistochemical visualisation of 5-bromo-2′-deoxyuridine (BrdU) incorporation into S-phase nuclei. The primary objective of this study was to determine whether treatment with phenobarbitone influenced the replicative states of specific cohorts of the islet (of Langerhans) cell population or generated a uniform depression of LI. Quantitation of the LIs of individual islet cell cohorts was achieved by utilisation of a dual immunohistochemical staining method for BrdU and islet hormones (insulin, glucagon and somatostatin) using a sequential peroxidase anti-peroxidase (PAP)/alkaline phosphatase anti-alkaline phosphatase (APAAP) method employing diaminobenzidine and New Fuchsin chromogens, respectively. We observed reductions, increases and no change in LIs of insulin-, glucagon- and somatostatin-positive cells, respectively. We conclude that the decreased LI of the insulin-positive cohort was not countered entirely by the LI increase in the glucagon-positive cohort due to the larger size of the former. Furthermore, the effects of phenobarbitone treatment are not manifested generally in the islet cell population but in the insulin- and glucagon-positive cohorts only. The causation of these effects is unknown but is likely to be due to enhanced carbohydrate and hormone metabolism. We believe that the visualisation and quantitation of replicating cells in specific hormone-positive cohorts of the islet cell population provide opportunities for understanding the influence of xenobiotics and disease processes on pancreatic function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050137
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  • 9
    Electronic Resource
    Electronic Resource
    Cytoplasmic granule formation in mouse pancreatic acinar cells. Evidence for formation of immature granules (condensing vacuoles) by aggregation and fusion of progranules of unit size, and for reductions in membrane surface area and immature granule volume during granule maturation (1994)
    Springer
    Cell & tissue research 278 (1994), S. 327-336 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Degranulation ; Pancreas ; Golgi complex ; Pilocarpine ; Unit granule formation ; Mouse (ICR)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. We used a computer-assisted morphometry approach to analyze quantitatively the process of cytoplasmic granule formation in mouse pancreatic acinar cells stimulated with pilocarpine to induce secretion. Our findings suggest that each condensing vacuole/immature granule of pancreatic acinar cells is formed by the progressive aggregation of 106 to 128 “unit progranules” of narrowly fixed volume, define a range of 7.7 to 9.2 for the factor of volume condensation between the largest immature granules and the mature unit granule, and predict that the formation of a single mature unit granule by the aggregation and fusion of unit progranules involves a net reduction of at least 95% in the amount of membrane surface area associated with these structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414176
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  • 10
    Electronic Resource
    Electronic Resource
    Distribution of the nuclear receptor for vitamin D in female and male zebra finches, Taeniopygia guttata (1994)
    Springer
    Cell & tissue research 276 (1994), S. 333-345 
    Details
    ISSN: 1432-0878
    Keywords: Vitamin D receptor ; Brain, vertebrate ; Immune system ; Heart ; Alimentary tract ; Pancreas ; Uropygial gland ; Taeniopygia guttata (Aves, Passeriformes)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this study, we describe the distribution of high affinity binding sites for 1,25(OH)2-vitamin D3 (1,25-D3) in the zebra finch (Taeniopygia guttata). Four hours following the injection of tritiated 1,25-D3, binding of the steroid hormone was found primarily in the cell nuclei of a variety of differnt organs. Neurons in numerous discrete regions of the forebrain were labeled. These forebrain regions included the nucleus accumbens, nucleus dorsomedialis posterior thalami, lobus parolfactorius, nucleus septalis lateralis and medialis, nucleus septalis, lamina medullaris dorsalis, nucleus striae terminalis, palaeostriatum augmentatum, and stratum griseum. The choroid plexuses, however, remained clear. Labeled cells were seen in several organs of the alimentary canal, in both the exocrine and the endocrine pancreas, in the proximal tubules of the kidney, in the spleen, in the bursa of Fabricius, and in the heart. The basal cells of the uropygial gland were also labeled. No specific retention was evident in the gonads of either sex. Vitamin D is thus bound by cells in systems with widely different functions. Since several of the labeled tissues are not primarily involved in calcium homeostasis, the data support the concept that vitamin D-soltriol is a steroid hormone that acts as a seasonal neuroendocrine-endocrine regulator and somatotrophic modulator.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306118
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  • 11
    Electronic Resource
    Electronic Resource
    Cytoplasmic granule formation in mouse pancreatic acinar cells. Evidence for formation of immature granules (condensing vacuoles) by aggregation and fusion of progranules of unit size, and for reductions in membrane surface area and immature granule volume during granule maturation (1994)
    Springer
    Cell & tissue research 278 (1994), S. 327-336 
    Details
    ISSN: 1432-0878
    Keywords: Degranulation ; Pancreas ; Golgi complex ; Pilocarpine ; Unit granule formation ; Mouse (ICR)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We used a computer-assisted morphometry approach to analyze quantitatively the process of cytoplasmic granule formation in mouse pancreatic acinar cells stimulated with pilocarpine to induce secretion. Our findings suggest that each condensing vacuole/immature granule of pancreatic acinar cells is formed by the progressive aggregation of 106 to 128 “unit progranules” of narrowly fixed volume, define a range of 7.7 to 9.2 for the factor of volume condensation between the largest immature granules and the mature unit granule, and predict that the formation of a single mature unit granule by the aggregation and fusion of unit progranules involves a net reduction of at least 95% in the amount of membrane surface area associated with these structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414176
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  • 12
    Electronic Resource
    Electronic Resource
    Endocrine tissue associated with the pancreatic ductal system: A light and electron microscopic study of the adult rat pancreas with special reference to a new endocrine arrangement (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 239 (1994), S. 371-378 
    Details
    ISSN: 0003-276X
    Keywords: Pancreas ; Pancreatic ducts ; Pancreatic hormones ; Islets of Langerhans ; Transmission electron microscopy ; Wistar rats ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Background: A substantial part of the endocrine pancreas has been previously described as being located either close to the excretory ducts as small clusters of endocrine cells and as Islets of Langerhans, or associated with the ducts as single endocrine cells scattered through the ductal epithelium.Methods: Four Wistar white adult rats were sacrificed and perfused via the thoracic aorta with 2.5% glutaraldehyde. After the usual treatment for the transmission electron microscopy, pieces of pancreas were sectioned consecutively for light microscopy. Consecutive ultrathin sections were performed in the most interesting cases.Results: The observations previously reported were confirmed. In addition, a new endocrine arrangement was detected and described as buds of endocrine cells (mainly B-cells) protruding from the ductal epithelium into the surrounding tissue.Conclusions: The authors propose to explain the endocrine buds as components of the gastro-entero-pancreatic system or as a stage of an endocrine pancreatic “neo-histogenesis” occurring in the adult rat pancreas. © 1994 Wiley-Liss, Inc.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092390404
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  • 13
    Electronic Resource
    Electronic Resource
    Infantile hepatic haemangioendothelioma: an association with hemihypertrophy (1993)
    Springer
    Pediatric surgery international 8 (1993), S. 505-506 
    Details
    ISSN: 1437-9813
    Keywords: Hemihypertrophy ; Haemangioendothelioma ; Hepatic vascular tumours ; Pancreas ; Cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 3-month-old infant with obvious hypertrophy affecting the right arm, leg, and face presented with a haemangioendothelioma arising from the right lobe of the liver that was not associated with cardiac failure. At diagnostic laparotomy the nature of the mass was confirmed and the right hepatic artery was ligated. Follow-up examination at 10 months revealed complete resolution of the intrahepatic mass. This appears to be the first report of an association between hemihypertrophy and hepatic haemangioendothelioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180356
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  • 14
    Electronic Resource
    Electronic Resource
    Leiomyosarcoma of the pancreas (1993)
    Springer
    Virchows Archiv 422 (1993), S. 419-422 
    Details
    ISSN: 1432-2307
    Keywords: Pancreas ; Leiomyosarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of leiomyosarcoma of the pancreas. A spindle cell pattern at light microscopy, immunocytochemical reactivity with desmin, alpha-1-antitrypsin, vimentin and actin and ultrastructural features of smooth muscle differentiation help to establish the diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605462
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  • 15
    Electronic Resource
    Electronic Resource
    Expression of progesterone receptors in solid-cystic tumour of the pancreas (1993)
    Springer
    Virchows Archiv 423 (1993), S. 425-431 
    Details
    ISSN: 1432-2307
    Keywords: Pancreas ; Solid-cystic tumour ; Progesterone receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A role for sex hormones in the pathogenesis of solid-cystic tumour (SCT) of the pancreas is suggested by its predilection for young fertile women. Controversial data have been provided for the presence of progesterone receptors (PR) and/or oestrogen receptors (ER) in SCT. We report the immunohistochemical detection of PR in ten cases of SCT. Eight were from young women. The remaining two were from a post-menopausal woman and a young boy. All cases showed PR immunoreactivity in the large majority of neoplastic cells, whereas none exhibited ER positivity. In one tumour two types of cell populations were noted, the more anaplastic invasivetype being PR negative, whereas the more typical was PR positive. PR immunoreactivity in the absence of ER may simply reflect a lower sensitivity of ER antibody failing to reveal the biochemically detectable ER, or that the PR in cells of SCT are constitutively synthesized in an oestrogen-independent way, as in T47D breast carcinoma cell line, meningioma cells and some gastric cancer cells. Our findings support the hypothesis of a possible pathogenetic role of progesterone in SCT, independent of the patient's sex and age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606531
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  • 16
    Electronic Resource
    Electronic Resource
    Fetal antigen 1 (FA1) in the human pancreas: cell type expression, topological and quantitative variations during development (1993)
    Springer
    Anatomy and embryology 187 (1993), S. 335-341 
    Details
    ISSN: 1432-0568
    Keywords: Fetal antigen 1 ; Insulin ; Pancreas ; Development ; Exocrine ; Endocrine ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monospecific rabbit anti-human fetal antigen 1 (FA1), was used to examine the distribution of FA1 during the development of the human fetal pancreas and liver using an indirect immunoperoxidase technique. FA1 was expressed by 94% of the glandular epithelial cells of the branching ducts in the pancreatic anlage at week 7 of gestation. This pattern changed during the development of the human pancreas, 64% of the glandular cells being FA1 positive at week 17 of gestation, decreasing to 11% in the infant (4 months after birth). In the infant and adults the FA1 expression was restricted to a subpopulation of β-cells within the islets of Langerhans. Insulin immunoreactive cells were scattered throughout the epithelium of primitive branching pancreatic ducts at week 7 of gestation, well before the formation of islets. From the 7th through to the 17th week of gestation, FA1 was found in the cytoplasm of fetal hepatocytes, whereas no staining was observed in the liver from a 4-month-old infant. No FA1 expression was found in the epithelium of the developing gut. The present findings indicate that the glandular epithelial cells in the developing pancreas may serve as stem cells, which, if appropriately induced, may differentiate into endocrine cells. Fetal antigen 1 (FA1) may take part in or be a result of this differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00185891
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  • 17
    Electronic Resource
    Electronic Resource
    Effect of secretin and inhibitors of HCO3 −/H+ transport on the membrane voltage of rat pancreatic duct cells (1993)
    Springer
    Pflügers Archiv 425 (1993), S. 272-279 
    Details
    ISSN: 1432-2013
    Keywords: Pancreas ; Ducts ; Secretin ; Acetate ; NH4 +/NH3 ; EIPA ; DIDS ; Ethoxzolamide ; K+ conductance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to study the effect of secretin on the electrophysiological response of pancreatic ducts. Furthermore, we investigated the effects of lipid-soluble buffers and inhibitors of HCO3 −/H+ transport. Ducts obtained from fresh rat pancreas were perfused in vitro. Secretin depolarized the basolateral membrane voltage, V bl, by up to 35 mV (n=37); a halfmaximal response was obtained at 3×10−11 mol/l. In unstimulated ducts a decrease in the luminal Cl− concentration (120 to 37 mmol/l) had a marginal effect on V bl, but after maximal secretin stimulation it evoked a 14±2 mV depolarization (n=6), showing that a luminal Cl− conductance G Cl- was activated. The depolarizing effect of secretin on V bl was often preceded by about a 6 mV hyperpolarization, most likely due to an increase in the basolateral G K+. Perfusion of ducts with DIDS (4,4′ — diisothiocyanatostilbene — 2,2′ — disulphonic acid, 0.01 mmol/l) or addition of ethoxzolamide (0.1 mmol/l) to the bath medium diminished the effect of secretin. Acetate or pre-treatment of ducts with NH4 +/NH3 (10 mmol/l in the bath) depolarized the resting V bl of −65±2 mV by 16±4 mV (n=7) and 19±3 mV (n=10), respectively. The fractional resistance of the basolateral membrane (FR bl) doubled, and the depolarizing responses to changes in bath K+ concentrations (5 to 20 mmol/l) decreased from 22±1 to 11±2 mV. The Na+/H+ antiporter blocker EIPA (5-[N-ethyl-N-isopropyl]-amiloride, 0.1 mmol/l) also depolarized V bl by 10±1 mV, FRbl increased and the response to K+ concentration changes decreased (n=7). Effects of EIPA and ethoxzolamide on V bl were greater in ducts deprived of exogenous HCO3 −/CO2. Taken together, the present study shows that secretin increased the basolateral G K+ and the luminal G Cl-. The depolarizing effect of secretin was diminished following inhibition of HCO3 − transport (DIDS), or HCO3 −/H+ generation (ethoxzolamide). Manoeuvres that presumably led to lowered intracellular pH (NH4 +/NH3 removal, acetate, EIPA) decreased the basolateral G K+. The present data support our previously published model for pancreatic HCO3 − secretion, and indicate that the basolateral membrane possesses a pH-sensitive G K+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374178
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  • 18
    Electronic Resource
    Electronic Resource
    Histiocytosis X revealed by pancreatic and pulmonary localisations (1993)
    Springer
    European radiology 3 (1993), S. 468-470 
    Details
    ISSN: 1432-1084
    Keywords: Computed tomography ; Histiocytosis X ; Lung ; Pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of simultaneous pancreatic and pulmonary localisation of histiocytosis X in a 20-year-old patient presenting with abdominal pain, cough and weight loss. Abdominal ultrasonography and CT showed a tumour in the pancreatic tail. High-resolution thoracic CT showed cystic and nodular lesions of the lung. Surgical ablation, histological and immunohistological examination proved the pancreatic localisation of the histiocytic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221426
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  • 19
    Electronic Resource
    Electronic Resource
    Assessment of the influence of subacute phenobarbitone administration on multi-tissue cell proliferation in the rat using bromodeoxyuridine immunocytochemistry (1993)
    Springer
    Archives of toxicology 67 (1993), S. 622-628 
    Details
    ISSN: 1432-0738
    Keywords: Cell proliferation ; Phenobarbitone ; Immunocytochemistry ; Bromodeoxyuridine (BrdU) ; Liver ; Kidney ; Pituitary ; Adrenal ; Testis ; Thyroid ; Pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of daily administration of phenobarbitone on the mitotic rates of several tissues were investigated by bromodeoxyuridine (BrdU) immunocytochemistry. Phenobarbitone (80 mg/kg per day) was dosed to AP Wistar male rats for up to 7 days and BrdU (10 mg/ml) was given by infusion at a rate of 10 μl/h via subcutaneously implanted osmotic minipumps for 2 days prior to necropsy on days 1, 2, 3, 5 and 7. BrdU-labelled nuclei were visualised by peroxidase-antiperoxidase immunocytochemistry and counts of the numbers of labelled cells (labelling index, LI%) made from at least 1000 cells per tissue section(s). The LIs of several tissues (testis, adrenal cortex and medulla, kidney distal convoluted tubule and exocrine pancreas) showed no statistical difference by comparison with controls. Several tissues exhibited characteristic responses to phenobarbitone administration. Pituitary and endocrine pancreas LIs were decreased while those of thyroid, liver and kidney proximal convoluted tubule were increased. The pattern of LI increase was unique to each tissue with liver (median and lateral lobes) increased two-fold on day 3 and returning to control levels thereafter while kidney proximal tubule LI rose gradually with time and remained elevated on day 7. Thyroid LI on day 1 was almost double that of day 0 control and increased steadily thereafter. These data illustrate the varied responses of different tissues to phenobarbitone exposure, namely, depression and stimulation of mitosis. The causation of these functional changes is discussed in relation to direct and indirect effects on functional parameters, especially enzyme induction, alterations in hormonal and growth factor status and receptor regulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974069
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  • 20
    Electronic Resource
    Electronic Resource
    Effect of vasoactive intestinal peptide, carbachol and other agonists on the membrane voltage of pancreatic duct cells (1993)
    Springer
    Pflügers Archiv 424 (1993), S. 315-320 
    Details
    ISSN: 1432-2013
    Keywords: Pancreas ; Ducts ; Cell membrane voltage ; Vasoactive intestinal peptide ; Carbachol ; Cholecystokinin ; Bombesin ; Neurotensin ; Substance P
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regulation of pancreatic exocrine secretion involves hormonal, neural and neurohormonal components. Many agonists are known to be effective in pancreatic acinar cells, but less is known about the ducts. Therefore, we wanted to investigate the influence of various agonists on isolated perfused pancreatic ducts and, as a physiological response, we measured the basolateral membrane voltage of the duct cells (V bl) with microelectrodes. Pancreatic ducts were dissected from pancreas of normal rats and bathed in a HCO3 −-containing solution. Under control conditions, the average V bl was between -50 and -70 mV. Vasoactive intestinal peptide (VIP) and carbachol (CCH) reversibly depolarized V bl when applied to the bath. VIP (9×10−9 mol/l) depolarized V bl from -72±3 mV to -53±3 mV (n=20) and CCH (10−5 mol/l) from -62±3 to -35±4mV (n=10). Furthermore, a decrease of the Cl− concentration in the lumen led to an increase of VIP-induced depolarization of V bl, suggesting that a luminal Cl− conductance was increased. Cholecystokinin (CCK, 10−10-10−7 mol/l) and bombesin (10−8, 10−5 mol/l), which stimulate pancreatic exocrine secretion in acini or whole glands, showed no significant effect on V bl of the duct cells tested in our preparation (n=7, 6). Neurotensin (10−8 mol/l) had a marked depolarizing effect in two out of ten cases; V bl depolarized from about -65 mV to-29 mV and the effect was reversible. Substance P (2×10−7 mol/l), alone or in combination with secretin, had no effect on V bl of the tested duct cells (n=11). We propose that the basolateral membrane of pancreatic duct cells possesses receptors for VIP, acetylcholine and neurotensin. CCK, bombesin and substance P had no detectable effects on V bl of the duct cells tested, which could be due to the lack of corresponding receptors on these cells, or due to the absence of electrophysiologically detectable effects, in spite of receptor presence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00384358
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  • 21
    Electronic Resource
    Electronic Resource
    Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells (1993)
    Springer
    Pflügers Archiv 422 (1993), S. 443-448 
    Details
    ISSN: 1432-2013
    Keywords: K+-channel ; Ca2+ ; Apamin ; Pancreas ; Insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The whole-cell configuration of the patchclamp technique was used to characterize the biophysical and pharmacological properties of an oscillating K+-current that can be induced by intracellular application of GTP[γS] in mouse pancreatic B cells (Ämmälä et al. 1991). These K+ conductance changes are evoked by periodic increases in the cytoplasmic Ca2+ concentration ([Ca2+]i) and transiently repolarize the B cell, thus inhibiting action-potential firing and giving rise to a bursting pattern. GTP[γS]-evoked oscillations in K+ conductance were reversibly suppressed by a high (300 μM) concentration of carbamylcholine. By contrast, α2-adrenoreceptor stimulation by 20 μM clonidine did not interfere with the oscillatory behaviour but evoked a small sustained outward current. At 0 mV membrane potential, the oscillating K+-current elicited by GTP[γS] was highly sensitive to extracellular tetraethylammonium (TEA; 70% block by 1 mM). The TEA-resistant component, which carried approximately 80% of the current at −40 mV, was affected neither by apamin (1 μM) nor by tolbutamide (500 μM). The current evoked by internal GTP[γS] was highly selective for K+, as demonstrated by a 51-mV change in the reversal potential for a sevenfold change in [K+]o. Stationary fluctuation analysis indicated a unitary conductance of 0.5 pS when measured with symmetric (≈ 140mM) KCl solutions. The estimated singlechannel conductance with physiological ionic gradients is 0.1 pS. The results indicate the existence of a novel Ca2+-gated K+ conductance in pancreatic B cells. Activation of this K+ current may contribute to the generation of the oscillatory electrical activity characterizing the B cell at intermediate glucose concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375069
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  • 22
    Electronic Resource
    Electronic Resource
    Specific cellular immune responses to pancreatic antigen in chronic pancreatitis and Sjögren's syndrome (1993)
    Springer
    Journal of clinical immunology 13 (1993), S. 265-271 
    Details
    ISSN: 1573-2592
    Keywords: Pancreas ; salivary gland ; chronic pancreatitis ; Sjögren's syndrome ; primary biliary cirrhosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The specific cellular immune response to the partially purified pancreatic antigen was studied by the peripheral blood lymphocyte proliferation assay in patients with chronic pancreatitis, Sjögren's syndrome, and primary biliary cirrhosis. A significant positive result (stimulation index 〉2.0) was observed in 7 of 21 patients with idiopathic chronic pancreatitis (33%;P〈0.05), 6 of 7 patients with Sjögren's syndrome-associated chronic pancreatitis (86%;P〈0.0005), and 6 of 11 patients with Sjögren's syndrome (55%;P〈0.01), compared to normal controls whose stimulation index was 0.94±0.28 (mean ± SD;n=14; range, 0.56–1.60). On the other hand, patients with alcoholic chronic pancreatitis (17%;n=12), stone-related chronic pancreatitis (0%;n=7), primary biliary cirrhosis-associated chronic pancreatitis (33%;n=3), primary biliary cirrhosis (0%;n=4), systemic lupus erythematosus (17%;n=6), and autoimmune thyroiditis (0%;n=6) showed no significant difference from normal controls. Furthermore, in patients with idiopathic chronic pancreatitis who had positive results, a lymphocyte proliferative response to the pancreatic antigen was observed in T cells, especially in the CD4+ T cell subpopulation. These results suggest that the pancreatic antigen plays a role in the pathogenesis of a part of idiopathic chronic pancreatitis and Sjögren's syndrome in association with T cell responses and, also, suggest that autoimmunity may be a possible etiological factor in chronic pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00919385
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  • 23
    Electronic Resource
    Electronic Resource
    Isolated pancreatic islets of the rat: An immunohistochemical and morphometric study (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 237 (1993), S. 489-497 
    Details
    ISSN: 0003-276X
    Keywords: Immunohistochemistry ; Isolated islets ; Morphometry ; Pancreas ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Although there is a recent increase in the use of the isolated pancreatic islets of the rat in the transplantation and functional studies, there has been no detailed quantitative assessment on the size and cellular constituents of islets after the isolation procedure. The present work was undertaken to study the size classes of the isolated islets and the morphometry of their cellular populations.Islets of the rat pancreas were isolated by using the intraductal collagenase digestion technique, the most commonly used procedure for the isolation of pancreatic islets. Different endocrine cells of the isolated islets were stained by immunoperoxidase staining techniques. The distribution of the cellular constituents of the isolated islets was similar to that of the intact islets of the normal pancreas; A, D, and PP cells were peripherally arranged around the centrally located B cells. However, morphometric quantitative study showed that the percent volume and percent number of A, D, and PP cells of the isolated islets were lower than those of the corresponding intact ones. Further, the mean true diameter of the isolated islets was lower than that of the intact ones. These data indicate loss of islet cells during the process of isolation. Most of the lost cells were from the periphery of islets. This may provide an explanation for the incomplete metabolic control and recurrence of hyperglycemia encountered after isolated islet transplantation in the treatment of diabetes mellitus. It seems that further refinements of the isolation techniques are necessary to obtain islet tissue with total cellular integrity, before a complete success in transplantation could be achieved. © 1993 Wiley-Liss, Inc.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092370408
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  • 24
    Electronic Resource
    Electronic Resource
    In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 197 (1993), S. 146-156 
    Details
    ISSN: 1058-8388
    Keywords: Embryonic development ; hXBP-1 ; Basic domain/leucine zipper protein ; Pancreas ; Salivary glands ; TIMP ; Alkaline phosphatase ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The spatial and temporal distribution of transcripts for the TRE/CRE-binding basic region-leucine zipper protein hXBP-1 was determined by in situ hybridization. Analysis of embryos from day 10.5 to 18.5 pc revealed high level expression of hXBP-1 RNA in two developing organ systems: (1) in bone and cartilage cells of the developing skeleton and toothbuds, and (2) in exocrine glands including the pancreas and the submandibular and salivary glands. High level expression was also found in whisker follicles and in selected cells in brown adipose tissue. In the developing skeleton, hXBP-1 RNA was expressed starting on day 11.5 pc in osteoblasts of newly formed intramembranous bone. Thereafter, hXBP-1 was expressed in both osteoblasts and preosteoblasts in bone formed directly by intramembranous formation as well as in bone formed during endochondral ossification. The most intese signal was observed in preosteoblasts and osteoblasts of newly forming bone. At day 11.5 pc low level hXBP-1 expression was also observed in matrix secreting chondroblasts of bones which are formed initially of cartilage, at the stage where they consist entirely of cartilage, at the stage where they consist entirely of cartilage. Signal was also present in matrix producing chondroblasts of the mature zone of the growth region during endochondral ossification although at significantly lower level than in osteoblasts. hXBP-1 is thus the first transcription factor described, to our knowledge, whose level of expression is modulated during the osteoblast developmental sequence in vivo. The pattern of expression of hXBP-1 in the developing skeleton was found to be very similar to that of the genes encoding the tissue inhibitor of metalloproteinase and alkaline phosphatase throughout development. These observations suggest that hXBP-1 may play a role in regulating the expression of tissue specific genes (TIMP, osteonectin, osteopontin, osteocalcin) expressed in osteoblasts. It is intriguing that the promoter regions of several such genes contain potential hXBP-1 binding sites. © 1993 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001970207
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