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1

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Parasite enzymes as potential targets for antiparasitic chemotherapy (1984)

Wang, Ching Chung

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 1-9

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a001

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2

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(E)-2-(3,4-dimethoxyphenyl)-3-fluoroallylamine: a selective, enzyme-activated inhibitor of type B monoamine oxidase (1984)

Bey, Philippe ; Fozard, John ; Lacoste, Jean Michel ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 9-10

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a002

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3

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Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate (1984)

Ajmera, Sudhir ; Bapat, Ashok R. ; Danenberg, Kathleen ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 11-14

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a003

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4

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Structure-activity relationship study of the inhibition of adrenal cortical 11.beta.-hydroxylase by new metyrapone analogs (1984)

Hays, Sheryl J. ; Tobes, Michael C. ; Gildersleeve, David L. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 15-19

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a004

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5

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Stereochemical considerations and the antiinflammatory activity of 6-amino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols and related derivatives (1984)

Wong, Shing Chun ; Sasso, Sandra ; Jones, Howard ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 20-27

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a005

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6

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Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine (1984)

Dandridge, Penelope A. ; Kaiser, Carl ; Brenner, Martin ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 28-35

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a006

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7

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Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines (1984)

Glennon, Richard A. ; Jacyno, John M. ; Young, R. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 41-45

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a008

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8

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Trypanocidal 1,3-arylene diketone bis(guanylhydrazones). Structure-activity relationships among substituted and heterocyclic analogs (1984)

Ulrich, Peter ; Cerami, Anthony

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 35-40

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a007

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9

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8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists (1984)

Arvidsson, Lars Erik ; Hacksell, Uli ; Johansson, Anette ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 45-51

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a009

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10

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Effect of tellurium position on the myocardial uptake of radioiodinated 18-iodotellura-17-octadecenoic acid analogs (1984)

Knapp, F. F. ; Srivastava, P. C. ; Callahan, A. P. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 57-63

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a011

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11

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Electronic structures of cephalosporins and penicillins. 15. Inductive effect of the 3-position side chain in cephalosporins (1984)

Boyd, Donald B.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 63-66

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a012

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12

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Palladium(II)-catalyzed olefin-coupling reactions of kainic acid: effects of substitution on the isopropenyl group on receptor binding (1984)

Conway, Gregory A. ; Park, Joon Sup ; Maggiora, Linda ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 52-56

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a010

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13

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A cannabinoid derived prototypical analgesic (1984)

Melvin, Lawrence S. ; Johnson, M. Ross ; Harbert, Charles A. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 67-71

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a013

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14

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Receptor binding sites of hypoglycemic sulfonylureas and related [(acylamino)alkyl]benzoic acids (1984)

Brown, George R. ; Foubister, Alan J.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 79-81

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a016

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15

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Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted-phenyl derivatives (1984)

Lantos, I. ; Bender, P. E. ; Razgaitis, K. A. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 72-75

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a014

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16

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Structure-activity relationships of phenytoin-like anticonvulsant drugs (1984)

Poupaert, Jacques H. ; Vandervorst, Daniel ; Guiot, Pierre ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 76-78

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a015

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17

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Novel tetracyclic spiropiperidines. 4. Synthesis and pharmacological evaluation of spiro- and 6,7-dihydrospiro[benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine-2H(1H),4'-piperidine]s (1984)

Glamkowski, Edward J. ; Fortunato, James M. ; Ong, Helen H. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 81-83

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ISSN: 1520-4804

Source: ACS Legacy Archives

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URL: http://dx.doi.org/10.1021/jm00367a017

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18

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2-Acetylpyridine thiosemicarbazones. 8. Derivatives of 1-acetylisoquinoline as potential antimalarial agents (1984)

Klayman, Daniel L. ; Scovill, John P. ; Bruce, Joseph ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 84-87

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ISSN: 1520-4804

Source: ACS Legacy Archives

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URL: http://dx.doi.org/10.1021/jm00367a018

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19

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2-Acetylpyridine thiosemicarbazones. 9. Derivatives of 2-acetylpyridine 1-oxide as potential antimalarial agents (1984)

Scovill, John P. ; Klayman, Daniel L. ; Lambros, Chris ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 87-91

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a019

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20

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Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)uracils (1984)

Watanabe, Kyoichi A. ; Su, Tsann Long ; Reichman, Uri ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 91-94

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a020

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21

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Synthesis and evaluation of radioiodinated (E)-18-iodo-17-octadecenoic acid as a model iodoalkenyl fatty acid for myocardial imaging (1984)

Knapp, F. F. ; Goodman, M. M. ; Kabalka, G. W. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 94-97

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a021

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22

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Book Reviews (1984)

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 100-102

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a600

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23

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cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino]cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor (1984)

Johnston, Thomas P. ; McCaleb, George S. ; Rose, William C. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 97-99

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00367a022

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24

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Design, synthesis, and testing of potential antisickling agents. 3. Ethacrynic acid (1984)

Kennedy, Paul E. ; Williams, Franki L. ; Abraham, Donald J.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 103-105

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URL: http://dx.doi.org/10.1021/jm00368a001

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25

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Design, synthesis, and binding characteristics of an opiate receptor mimetic peptide (1984)

Kullmann, Willi

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 106-115

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a002

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26

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Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides (1984)

Honma, Yasushi ; Hanamoto, Kyoji ; Hashiyama, Tomiki ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 125-128

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URL: http://dx.doi.org/10.1021/jm00368a005

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27

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Synthesis of 2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl) benzo heterocycles. A novel series of orally active antiallergic agents (1984)

Musser, John H. ; Brown, Richard E. ; Loev, Bernard ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 121-125

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a004

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28

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Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity (1984)

Almquist, Ronald G. ; Olsen, Cris M. ; Uyeno, Edward T. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 115-120

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a003

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29

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Crystallography, quantitative structure-activity relationships, (QSAR) and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines (1984)

Hansch, Corwin ; Hathaway, Bruce A. ; Guo, Zongru ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 129-143

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a006

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30

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Adrenal medulla imaging agents: a structure-distribution relationship study of radiolabeled aralkylguanidines (1984)

Wieland, Donald M. ; Mangner, Thomas J. ; Inbasekaran, Muthiah N. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 149-155

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a008

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31

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Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. A quantitative structure-activity relationship analysis (1984)

Hathaway, Bruce A. ; Guo, Zong Ru ; Hansch, Corwin ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 144-149

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a007

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32

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Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(4-iodophenyl)-.alpha.-phenylacetate as potential radiopharmaceuticals (1984)

Rzeszotarski, W. J. ; Eckelman, W. C. ; Francis, B. E. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 156-160

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a009

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33

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Synthesis of 3-hydroxy-2- and -4-pyridone nucleosides as potential antitumor agents (1984)

Mao, David T. ; Driscoll, John S. ; Marquez, Victor E.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 160-164

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a010

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Design, synthesis, and x-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties (1984)

Imhof, Rene ; Kyburz, Emilio ; Daly, John J.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 165-175

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a011

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35

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Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III (1984)

Wright, George E. ; Gambino, Joseph J.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 181-185

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a013

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36

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Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase .alpha. (1984)

Wright, George E. ; Dudycz, Lech W.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 175-181

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a012

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37

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Resorcinol congeners of dopamine derived from benzocycloheptene and indan (1984)

Cannon, Joseph G. ; Pease, Jonathan P. ; Hamer, Richard L. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 186-189

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a014

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Conformationally restricted congeners of dopamine derived from octahydrobenzo[g]quinoline and octahydrobenzo[f]quinoline (1984)

Cannon, Joseph G. ; Hamer, Richard L. ; Ilhan, Mustafa ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 190-195

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00368a015

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39

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Synthesis and anticonvulsant activity of some substituted lactams and amides (1984)

Brouillette, Wayne J. ; Grunewald, Gary L.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 202-206

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URL: http://dx.doi.org/10.1021/jm00368a017

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40

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Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, a novel broad-spectrum antitumor agent (1984)

Stevens, Malcolm F. G. ; Hickman, John A. ; Stone, Robert ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 196-201

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41

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Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties (1984)

Sablayrolles, Claire ; Milhavet, Jean Claude ; Rechenq, Eliane ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 206-212

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42

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Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds (1984)

Terada, Atsusuke ; Naruto, Shunji ; Wachi, Kazuyuki ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 212-216

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Synthesis and antimicrobial activity of clindamycin analogs: pirlimycin, a potent antibacterial agent (1984)

Birkenmeyer, Robert D. ; Kroll, Stephen J. ; Lewis, Charles ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 216-223

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Studies on 1,2,3,-triazoles. 10. Synthesis and antiallergic properties of 9-oxo-1H,9H-benzothiopyrano[2,3-d]-1,2,3-triazoles and their S-oxides (1984)

Buckle, Derek R. ; Rockell, Caroline J. M. ; Smith, Harry ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 223-227

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Design and synthesis of tetrahedral intermediate analogs as potential dihydroorotase inhibitors (1984)

Levenson, Corey H. ; Meyer, Rich B.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 228-232

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Improved synthesis and antitumor evaluation of 5,8-dideazaisofolic acid and closely related analogs (1984)

Hynes, J. B. ; Yang, Y. C. S. ; McGill, J. E. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 232-235

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Antileukemic compounds derived by chemical modification of macrocyclic trichothecenes. 2. Derivatives of roridins A and H and verrucarins A and J (1984)

Jarvis, Bruce B. ; Midiwo, Jacob O. ; Mazzola, Eugene P.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 239-244

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Book Reviews (1984)

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 244-246

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Novel N-hydroxyguanidine derivatives as anticancer and antiviral agents (1984)

Tai, Anna W. ; Lien, Eric J. ; Lai, Michael M. C. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 236-238

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50

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Dependence of .beta.-lactamase stability on substructures within .beta.-lactam antibiotics (1984)

Cimarusti, Christopher M.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 247-253

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51

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5-[(Aminoalkyl)amino]-substituted anthra[1,9-cd]pyrazol-6(2H)-ones as novel anticancer agents. Synthesis and biological evaluation (1984)

Showalter, H. D. Hollis ; Johnson, Judith L. ; Werbel, Leslie M. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 253-255

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N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor (1984)

Sestanj, Kazimir ; Bellini, Francesco ; Fung, Steven ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 255-256

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A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria (1984)

Friend, David R. ; Chang, George W.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 261-266

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Synthesis and biological activity of nucleosides and nucleotides related to the antitumor agent 2-.beta.-D-ribofuranosylthiazole-4-carboxamide (1984)

Srivastava, Prem C. ; Revankar, Ganapathi R. ; Robins, Roland K.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 266-269

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Cardiac glycosides. 1. A systematic study of digitoxigenin D-glycosides (1984)

Fullerton, Dwight S. ; Kihara, Masaru ; Deffo, Tamboue ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 256-261

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Synthesis and evaluation of a series of 2'-O-acyl derivatives of 9-.beta.-D-arabinofuranosyladenine as antiherpes agents (1984)

Baker, David C. ; Kumar, S. D. ; Waites, William J. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 270-274

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Adenosine deaminase inhibitors. Synthesis of deaza analogs of erythro-9-(2-hydroxy-3-nonyl) adenine (1984)

Antonini, Ippolito ; Cristalli, Gloria ; Franchetti, Palmarisa ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 274-278

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Structure-activity relationships of sparsomycin and its analogs: octylsparsomycin: The first analog more active than sparsomycin (1984)

Liskamp, Rob M. J. ; Colstee, J. Hans ; Ottenheijm, Harry C. J. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 301-306

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Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogs: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyridine against herpes simplex virus type 1 (1984)

Bergstrom, Donald E. ; Ruth, Jerry L. ; Reddy, P. Anantha ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 279-284

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Antiviral activity of C-5 substituted tubercidin analogs (1984)

Bergstrom, Donald E. ; Brattesani, Alan J. ; Ogawa, Mark K. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 285-292

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1,4-Dihydro-4-oxopyridinecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent (1984)

Matsumoto, Junichi ; Miyamoto, Teruyuki ; Minamida, Akira ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 292-301

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Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4,4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid (1984)

Hogberg, Thomas ; Khanna, Ish ; Drake, Steven D. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 306-310

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Structure activity studies on the N-terminal region of glucagon (1984)

Sueiras-Diaz, Javier ; Lance, Valentine A. ; Murphy, William A. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 310-315

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Angiotensin II: dependence of hormone affinity on the electronegativity of a single side chain (1984)

Guillemette, Gaetan ; Bernier, Michel ; Parent, Paul ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 315-320

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Synthesis of a novel class of heteroaromatic amino acids and their use in the preparation of analogs of luteinizing hormone-releasing hormone (1984)

Nestor, John J. ; Horner, Bonnie L. ; Ho, Teresa L. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 320-325

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Tri- and tetrapeptide analogs of kinins as potential renal vasodilators (1984)

Pfeiffer, Francis R. ; Chambers, Pamela A. ; Hilbert, Eileen E. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 325-341

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Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate (1984)

Selassie, Cynthia Dias ; Hansch, Corwin ; Khwaja, Tasneem A. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 347-357

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Studies of the mode of action of antitumor triazenes and triazines. 6. 1-Aryl-3-(hydroxymethyl)-3-methyltriazenes: synthesis, chemistry, and antitumor properties (1984)

Vaughan, Keith ; Tang, York ; Llanos, Gerard ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 357-363

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Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine (1984)

Denny, William A. ; Atwell, Graham J. ; Baguley, Bruce C.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 363-367

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Cytochrome P-450 complex formation in the metabolism of phenylalkylamines. 8. Stereoselectivity in metabolic intermediary complex formation with a series of chiral 2-substituted 1-phenyl-2-aminoethanes (1984)

Paulsen-Soerman, Ulla B. ; Joensson, Karl Henrik ; Lindeke, Bjoern G. A.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 342-346

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Dibenz[b,c]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-yl)butanol and -butyric acid and related derivatives (1984)

Martin, Lawrence L. ; Setescak, Linda L. ; Spaulding, Theodore C. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 372-376

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Synthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterins (1984)

DeGraw, J. I. ; Christie, P. H. ; Brown, E. G. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 376-380

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Potential antitumor agents. 41. Analogs of amsacrine with electron-donor substituents in the anilino ring (1984)

Atwell, Graham J. ; Rewcastle, Gordon W. ; Denny, William A. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 367-372

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6-Hydroxy-4-[2-di-n-propylaminoethyl]indole: synthesis and dopaminergic actions (1984)

Cannon, Joseph G. ; Lee, Teresa ; Ilhan, Mustafa ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 386-389

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Synthesis and evaluation of radioiodinated terminal para-iodophenyl-substituted .alpha.- and .beta.-methyl-branched fatty acids (1984)

Goodman, M. M. ; Kirsch, G. ; Knapp, F. F.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 390-397

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(Imidazolylphenyl)formamidines. A structurally novel class of potent histamine H2 receptor antagonists (1984)

Donetti, Arturo ; Cereda, Enzo ; Bellora, Elio ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 380-386

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(.+-.)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 3. 2-Phenyl and 2-amino analogs as potential antihypertensive agents (1984)

Setescak, Linda L. ; Dekow, Frederick W. ; Kitzen, Jan M. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 401-404

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Phosphorus-nitrogen compounds. 24. Phosphoramide mustard carrier derivatives (1984)

Cates, Lindley A. ; Li, Ven Shun ; Powell, Douglas R. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 397-401

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A cyclic angiotensin antagonist: [1,8-cysteine)angiotensin II (1984)

Matsoukas, John M. ; Scanlon, Martin N. ; Moore, Graham J.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 404-406

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Acetylenic nucleosides. Synthesis and biological activities of some 5-ethynylpyrimidine nucleosides (1984)

Sharma, Ram A. ; Kavai, Ivan ; Hughes, Robert G. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 410-412

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Synthesis of certain hydroxy analogs of the antimalarial drug primaquine and their in vitro methemoglobin-producing and glutathione-depleting activity in human erythrocytes (1984)

Allahyari, Reza ; Strother, Allen ; Fraser, Ian M. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 407-410

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/jm00369a031

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82

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Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid (1984)

Boettcher, Irmgard ; Elger, Walter ; Kirsch, Gerald ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 413-414

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00369a033

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Book Reviews (1984)

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 415-416

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00369a600

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84

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Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes (1984)

Rich, Daniel H. ; Moon, Byung Jo ; Harbeson, Scott

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 417-422

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a001

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85

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Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids (1984)

Wong, Corinne G. ; Meyer, Rich B.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 429-432

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ISSN: 1520-4804

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a003

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86

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2,3,4,4a,5,9b-Hexahydro-1H-indeno[1,2-b]pyridines: potential antidepressants (1984)

Kunstmann, Rudolf ; Lerch, Ulrich ; Gerhards, Hermann ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 432-439

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a004

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87

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Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine (1984)

Hunston, Roger N. ; Jones, A. Stanley ; McGuigan, Christopher ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 440-444

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a005

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88

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Synthesis and antitumor activity of cis-dichloroplatinum(II)-N-aminated nucleoside (1984)

Maeda, Mitsuaki ; Abiko, Noriko ; Uchida, Hiroyuki ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 444-449

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a006

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Potent and selective antagonists of the antidiuretic responses to arginine-vasopressin based on modifications of [1-(.beta.-mercapto-.beta.,.beta.-pentamethylenepropionic acid), 2-D-isoleucine, 4-valine]arginine-vasopressin at position 4 (1984)

Manning, Maurice ; Nawrocka, Eleonora ; Misicka, Aleksandra ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 423-429

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a002

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90

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Interactions of antitumor drugs with natural DNA: proton NMR study of binding mode and kinetics (1984)

Feigon, Juli ; Denny, William A. ; Leupin, Werner ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 450-465

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URL: http://dx.doi.org/10.1021/jm00370a007

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91

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Base-catalyzed hydrolysis of 4-hydroperoxycyclophosphamide: evidence for iminocyclophosphamide as an intermediate (1984)

Borch, Richard F. ; Getman, Kathleen M.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 485-490

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a009

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92

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NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways (1984)

Zon, Gerald ; Ludeman, Susan Marie ; Brandt, Joan A. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 466-485

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URL: http://dx.doi.org/10.1021/jm00370a008

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93

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Quantitative relationships between .alpha.-adrenergic activity and binding affinity of .alpha.-adrenoceptor agonists and antagonists (1984)

Timmermans, Pieter B. M. W. M. ; De Jonge, Adriaan ; Thoolen, Martin J. M. C. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 495-503

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Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a011

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94

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.beta.1-Selective adrenoceptor antagonists. 3. 4-Azolyl linked phenoxypropanolamines (1984)

Machin, Peter J. ; Hurst, David N. ; Bradshaw, Rachel M. ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 503-509

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a012

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95

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In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: proton and phosphorus-31 NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its hydrate in aqueous solution (1984)

Borch, Richard F. ; Hoye, Thomas R. ; Swanson, Todd A.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 490-494

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URL: http://dx.doi.org/10.1021/jm00370a010

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96

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Synthesis, receptor binding, and target-tissue uptake of carbon-11 labeled carbamate derivatives of estradiol and hexestrol (1984)

Ouellet, Rene ; Rousseau, Jacques ; Brasseur, Nicole ; [et al.]

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 509-513

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a013

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97

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Synthesis and physicochemical and neurotoxicity studies of 1-(4-substituted-2,5-dihydroxyphenyl)-2-aminoethane analogs of 6-hydroxydopamine (1984)

Cheng, Alice C. ; Castagnoli, Neal

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 513-520

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URL: http://dx.doi.org/10.1021/jm00370a014

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98

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Analgesics of the orvinol type. 19-Deoxy and 6,20-epoxy derivatives (1984)

Hutchins, Charles W. ; Rapoport, Henry

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 521-527

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URL: http://dx.doi.org/10.1021/jm00370a015

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99

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8-Methoxypsoralen-nucleic acid photoreaction. Effect of methyl substitution on pyrone vs. furan photoaddition (1984)

Kanne, David ; Rapoport, Henry ; Hearst, John E.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 531-534

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Topics: Chemistry and Pharmacology

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URL: http://dx.doi.org/10.1021/jm00370a017

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100

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(.+-.)-3-(4-Amino-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-5-(hydroxymethyl)-(1.alpha.,2.alpha.,3.beta.,5.beta.)-1,2-cyclopentanediol, the carbocyclic analog of tubercidin (1984)

Secrist, John A. ; Clayton, Sarah Jo ; Montgomery, John A.

s.l. : American Chemical Society

Journal of medicinal chemistry 27 (1984), S. 534-536

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URL: http://dx.doi.org/10.1021/jm00370a018

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