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  • 1980-1984  (2)
  • 1965-1969  (3)
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  • 1955-1959
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  • 1980  (2)
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  • Squirrel monkey
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Materialart
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  • 1980-1984  (2)
  • 1965-1969  (3)
  • 1960-1964
  • 1955-1959
  • 1950-1954
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Jahr
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  • 1
    Digitale Medien
    Digitale Medien
    Fixed ratio schedules of food presentation and stimulus shock termination: Effects of d-amphetamine, morphine, and clozapine (1980)
    Springer
    Psychopharmacology 70 (1980), S. 35-39 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Eixed ratio schedule ; Food ; Electric shock ; d-amphetamine ; Morphine ; Clozapine ; Squirrel monkey
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Squirrel monkeys responded under a multiple schedule in which 30 responses during a specified time limit resulted in either food presentation or termination of visual stimuli associated with impending shock delivery. Schedule components were associated with different colored lights and were separated by 60-s timeout periods in which all lights were extinguished. If the response requirement was not met within the time limit, either the time-out period alone (food components) was presented or a single shock was delivered coincident with onset of time-out. In experiments with d-amphetamine, different control rates of responding were engendered by varying the time limit. When the time limit was 60 s, all monkeys responded at higher overall rates during food presentation components. When the time limit was reduced to 15s, rates of responding in both components increased and became more similar than under the 60-s limit. When control rates in the two components differed under the 60-s time limit, d-amphetamine sulfate (0.01–1.0 mg/kg) increased the normally lower rates under the shock schedule at intermediate doses, but generally only decreased the higher rates under the food schedule. With more comparable control rates under the 15-s time limit, the effects of amphetamine were also more comparable. In most cases low and moderate doses either had little effect or slightly increased responding in both schedule components and higher doses decreased responding. Morphine sulfate (0.03–1.7 mg/kg) and clozapine (0.1 – 3.0 mg/kg) decreased responding comparably under both food and shock schedules with the 15-s time limit.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00432367
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  • 2
    Digitale Medien
    Digitale Medien
    Neuroleptic-induced acute dyskinesias in squirrel monkeys: Correlation with propensity to cause extrapyramidal side effects (1980)
    Springer
    Psychopharmacology 68 (1980), S. 25-29 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Dyskinesia ; Dystonia ; Neuroleptics ; Haloperidol ; Thioridazine ; Clozapine ; Squirrel monkey
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In squirrel monkeys that had undergone repeated treatment with haloperidol at intervals of 7–14 days, subsequent acute administration of haloperidol induced dystonia and dyskinesias. This acute effect of haloperidol was dose-related and occurred at the same doses that impaired Sidman avoidance performance. Chlorpromazine, fluphenazine, metoclopramide, tetrabenazine, and Su-23397, all of which have been associated with extrapyramidal side effects, reliably elicited dyskinesias in these monkeys. Dyskinesias were less marked after thioridazine and absent after clozapine, corresponding to the reported lower incidence of extrapyramidal side effects in the clinic. The non-neuroleptics, baclofen, and diazepam, failed to elicit dyskinesias. In contrast to the dyskinetic syndrome, the incidence of catalepsy or tremor did not accurately predict propensity to elicit extrapyramidal symptomatology. The acute dyskinetic syndrome in squirrel monkeys may therefore serve as an animal model for predicting the ability of antipsychotics to cause extrapyramidal dysfunction, and may yield insight into the mechanisms of these drug-induced motor disorders.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00426645
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  • 3
    Digitale Medien
    Digitale Medien
    Neurophysiological correlates of brightness discrimination in the lateral geniculate nucleus of the squirrel monkey (1966)
    Springer
    Experimental brain research 2 (1966), S. 1-17 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Brightness discrimination ; Lateral geniculate ; Squirrel monkey
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Incremental brightness thresholds (DI) were psychophysically determined at several background illumination intensities for three squirrel monkeys. Gross asymmetrical electrodes were then chronically implanted in the lateral geniculate nucleus of the same animals, and activity was recorded in stimulus conditions identical to behavioral testing. Overall activity, recorded through an integrating voltmeter, showed 1. a tendency to decrease as steady background illumination increased, and 2. an abrupt transient increase at both onset and offset to DI test flashes, directly proportional to test flash intensity. Background illumination, in proportion to its intensity, depressed response to a superimposed test flash. Test flashes below intensity DI at the various levels of background illumination produced no measurable response. The quantity DI was shown to be a function of the depressive or inhibitory effect of background illumination on the capacity of the system to respond to transient stimulation. A secondary determinant of DI appeared to be the amount of variability in ongoing neural activity upon which the DI flash is imposed. The author is indebted to the supervisor of her dissertation, Dr. L. R. Pinneo, for introducing her to the recording technique and for his help towards the completion of this work.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00234357
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  • 4
    Digitale Medien
    Digitale Medien
    Histochemical mapping of succinic dehydrogenase and cytochrome oxidase in the spinal cord, medulla oblongata and cerebellum of squirrel monkey (Saimiri sciureus) (1966)
    Springer
    Experimental brain research 2 (1966), S. 216-229 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Squirrel monkey ; Brain stem-Histochemical mapping ; Succinic dehydrogenase ; Cytochrome oxidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The distribution of succinic dehydrogenase (SDA) and cytochrome oxidase (Cy. O) in serial sections of the cervical region of the spinal cord and the medulla oblongata, arranged caudo-cranially, has been described. The motor cranial nerve nuclei exhibit strong SDA and Cy. O activity in the neurons and neuropil. The nuclei gracilis, cuneatus, olivaris inferior, cochlearis and vestibularis likewise show strong enzyme activity. Nucleus intercalatus and nucleus tractus solitarius, however, show weak and moderate enzyme activity respectively. The lateral part of formatio reticularis myelencephali shows less SDA and Cy. O compared to the medial part, which shows some accumulation of these enzymes in the neuropil. The neuropil of the molecular layer of cerebellar cortex and the perikarya and dendrites of the Purkinje cells show strong SDA and Cy. O activity. The granular layer exhibits stronger SDA and Cy. O in the synaptic glomeruli. The cerebellar nuclei possess stronger enzyme activity in the neurons and dendritic branches, compared to mild activity in the neuropil.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236714
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  • 5
    Digitale Medien
    Digitale Medien
    Histochemical mapping of succinic dehydrogenase and cytochrome oxidase in the pons and mesencephalon of squirrel monkey (Saimiri sciureus) (1966)
    Springer
    Experimental brain research 2 (1966), S. 230-246 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Squirrel monkey ; Midbrain ; Histochemical mapping ; Succinic dehydrogenase ; Cytochrome oxidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The distribution of succinic dehydrogenase (SDA) and cytochrome oxidase (Cy. O) has been investigated in a series of sections through the pons and mesencephalon of the squirrel monkey brain. The localization of the two enzymes is very similar in the various regions and shows only slight differences. The epiphysis, however, shows moderately strong SDA and very mild Cy. O activity. Particularly strong SDA and Cy. O activity has been observed in the cell bodies of the various cranial nerve nuclei, nucleus colliculi inferioris, colliculi superioris, nuclei griseum pontis, reticularis tegmenti pontis, lemnisci lateralis pars dorsalis, geniculatum laterale and mediale, and pulvinaris. The enzyme content of the neurons and cell bodies is generally stronger compared to the neuropil which often occurs in smooth, loose, compact and reticulated forms. Any special relationship between the neurons and neuropil with regard to their enzyme content has, however, not been observed. The cranial nerves, and fibers of the brachium conjunctivum, corpus callosum, and fornix show very mild enzyme activity except those of the trapezoid complex which show moderate enzyme activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236715
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