ISSN:
0749-1581
Keywords:
Platinum complexes
;
195Pt NMR
;
1H NMR
;
Ethylenediamine
;
Dimethylethylenediamine
;
Tetramethylethylenediamine
;
Hydrolysis
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The hydrolysis reactions of complexes of the type Pt(L)X2 where L is ethylenediamine (en), N,N- dimethylenediamine (N,N-Me2en), N,N-dimethylenediamine (N,N′-Me2en) and N,N,N′, N′-tetramethylethylenediamine (Me4en) were studied. The halo ligands were removed by precipitation with AgNO3 and the pH of the resulting filtrate, which was about 2, was adjusted to 5.8 (pD = 6.2). The study of the products formed was carried out by multinuclear NMR spectroscopy. The 195Pt NMR spectra showed the presence of several hydrolysed products, especially with en. The hydroxo-bridged dimer can be synthesized in a pure state with all the ligands except en. The results on the latter ligand contradict the published results on the synthesis of the en hydroxo-bridged dimer whose biological properties were studied. When Pt(L)I2 is used as starting material a small quantity of chloro species was always observed, indicating that the reactant contained a small quantity of Pt(L)ICI. The crystal structure of the [Pt(N,N-Me2en)(μ-OH)]2(NO3)2 dimer was determined. The compound belongs to the P21/c space group, with a = 8.262(5), b = 10.960(8), c = 11.405(8), β = 121.07(5)°, Z = 2 and ρcalc = 2.720 mg m-3. The results showed that this is the trans isomer with an inversion centre between the two Pt atoms. There is a considerable strain inside the four-membered ring, as shown by the reduced internal angles O—Pt—O′ = 79.1(6)0 and Pt—O—Pt′ = 101.0(6)°.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260300803
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