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Digitale Medien

Analysis of metastatic competence of mouse bladder carcinoma cells after transfection with activated Ha-ras or N-ras oncogenes (1988)

Pohl, J. ; Radler-Pohl, A. ; Franks, L. M. ; [weitere]

Springer

Journal of cancer research and clinical oncology 114 (1988), S. 373-379

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ISSN: 1432-1335

Schlagwort(e): Oncogene ; Ras ; Metastasis ; Transfection

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Transfection of the Ha-ras oncogene into a low metastatic epithelial cell line resulted in the acquirement of significantly increased metastatic capacity. This alteration in metastatic competence of a carcinoma line in a syngeneic system seemed to be a selective change and was not affected by parameters such as tumor latency period or local tumor growth. Transfection of the selection marker vectors with normal cellular DNA or with the N-ras gene did not lead to significantly increased metastatic capacity. Analysis of metastatic variants after oncogene transfection and in vivo selection showed integration of N-ras, but not of Ha-ras oncogenes. A possible role for the Ha-ras oncogene in the initial steps of metastasis will be discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02128181

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Digitale Medien

Onderzoekingen over stuifbrand (1944)

Oort, A. J. P.

Springer

European journal of plant pathology 50 (1944), S. 73-106

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ISSN: 1573-8469

Schlagwort(e): Dwerg ; Gemiddelde ; Gewas ; „Gezond” ; Graad van aantasting ; Herkomst ; Herstel ; Kieming ; Kiemplant ; Klein ; Overgevoelig ; Physio ; Ras ; Rijping ; Stuifbrand ; Vatbaar ; Volwassen plant ; „Ziek” ; dwarf ; mean ; crop ; in relation to seedlings: normal ; degree of attack ; origin ; recovering ; germination ; seedling ; small ; hypersensitive ; physiologic race ; variety ; maturation ; smut ; susceptible ; mature plant ; in relation to seedlings: abnormal