Digitale Medien
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Biochemistry
67 (1998), S. 181-198
ISSN:
0066-4154
Quelle:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Thema:
Chemie und Pharmazie
,
Biologie
Notizen:
Abstract Base flipping is the phenomenon whereby a base in normal B-DNA is swung completely out of the helix into an extrahelical position. It was discovered in 1994 when the first co-crystal structure was reported for a cytosine-5 DNA methyltransferase binding to DNA. Since then it has been shown to occur in many systems where enzymes need access to a DNA base to perform chemistry on it. Many DNA glycosylases that remove abnormal bases from DNA use this mechanism. This review describes systems known to use base flipping as well as many systems where it is likely to occur but has not yet been rigorously demonstrated. The mechanism and evolution of base flipping are also discussed.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1146/annurev.biochem.67.1.181
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