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Digitale Medien

Cimetidine impairs the elimination of chlormethiazole (1981)

Shaw, G. ; Bury, R. W. ; Mashford, M. L. ; [weitere]

Springer

European journal of clinical pharmacology 21 (1981), S. 83-85

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Details

ISSN: 1432-1041

Schlagwort(e): cimetidine ; chlormethiazole ; enzyme inhibition

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Cimetidine impairs the systemic clearance of a number of low extraction drugs and this study examines its effect on the oral clearance of the high extraction drug, chlormethiazole. Cimetidine (1 g/day for 7 days) caused the clearance of chlormethiazole to fall to 69% of pretreatment values. It also prolonged the elimination half-life by 60%. The findings indicate that the metabolism of chlormethiazole is inhibited by cimetidine and the co-administration of these drugs may lead to excess sedation and respiratory depression.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00609593

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