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  • 1
    Electronic Resource
    Electronic Resource
    The effect of ethanol administration on the disposition and elimination of chlormethiazole (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 383-385 
    Details
    ISSN: 1432-1041
    Keywords: ethanol ; chlormethiazole ; enzyme inhibition ; hepatic blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acutely administered ethanol has been shown to inhibit the hepatic metabolism of a number of drugs. Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients. Chlormethiazole has a narrow therapeutic index and the unexpected deaths reported in alcoholics taking this drug may have been due to an effect of ethanol on the metabolism of chlormethiazole. However in this study, acutely administered ethanol maintained at levels around 22 mmol/l had no significant effect on the disposition or elimination of either orally or intravenously administered chlormethiazole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00610059
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cimetidine impairs the elimination of chlormethiazole (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 83-85 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; chlormethiazole ; enzyme inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Cimetidine impairs the systemic clearance of a number of low extraction drugs and this study examines its effect on the oral clearance of the high extraction drug, chlormethiazole. Cimetidine (1 g/day for 7 days) caused the clearance of chlormethiazole to fall to 69% of pretreatment values. It also prolonged the elimination half-life by 60%. The findings indicate that the metabolism of chlormethiazole is inhibited by cimetidine and the co-administration of these drugs may lead to excess sedation and respiratory depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609593
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of impairment of renal function on the accumulation and disposition of isoxicam (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 585-588 
    Details
    ISSN: 1432-1041
    Keywords: isoxicam ; pharmacokinetics ; renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544071
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A PHARMACOLOGICAL INVESTIGATION OF SYNTHETIC SUBSTANCE P ON THE ISOLATED GUINEA-PIG ILEUM (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The pharmacological properties of synthetic substance P have been studied on the guinea-pig ileum and compared with those of acetylcholine and other agonists.2. The effects of synthetic substance P in the presence of atropine, hexamethonium, mepyramine and certain of the drugs which antagonize serotonin are in close agreement with those reported for the naturally occurring peptide.3. The spasmogenic action of substance P is not mediated by cholinergic mechanisms or release of prostaglandins, and does not appear to involve release of serotonin. The inability of tetrodotoxin to attenuate responses to substance P suggests that its spasmogenic action is not elicited through neural mechanisms. Thus, it is likely that substance P acts directly on the smooth muscle of the ileum.4. Since substance P is present in the brain and can depolarize neurones, it may be a neurotransmitter. A screening of various centrally acting drugs, whose mechanisms of action are unclear, was undertaken to seek possible interactions with substance P. Pimozide was the most potent in depressing responses to substance P but none of the drugs caused the specific antagonism which would assist in elucidating a possible physiological role for substance P.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02409.x
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    Paper (German National Licenses)
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