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Effect of impairment of renal function on the accumulation and disposition of isoxicam (1985)

Bury, R. W. ; Whitworth, J. A. ; Saines, D. ; [et al.]

Springer

European journal of clinical pharmacology 28 (1985), S. 585-588

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ISSN: 1432-1041

Keywords: isoxicam ; pharmacokinetics ; renal failure

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00544071

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HAEMODYNAMIC RESPONSE TO ACTH ADMINISTRATION IN ESSENTIAL HYPERTENSION (1981)

Whitworth, Judith A. ; Saines, D. ; Andrews, J. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental pharmacology and physiology 8 (1981), S. 0

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ISSN: 1440-1681

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: 1.The haemodynamic and volume response to ACTH administration was investigated in six patients with mild, untreated essential hypertension and two patients with Addison's disease on maintenance steroids. Blood pressure, heart rate and weight were recorded daily. Plasma volume (125I-HSA) and cardiac output (thermo-dilution) were measured during the control period and on the 5th day of ACTH treatment.2. In the hypertensive subjects, mean arterial pressure rose from 94.3 ± 2.2 to 105.7 ± 2.8 mmHg on the 5th day of ACTH administration (P〈0.02). Plasma volume rose from 29.8 ± 2.2 to 34 ± 2.2 ml/kg. Cardiac index increased from 2.85 ± 0.21 to 3.32 ± 0.14 l/min per m2 (P〈0.05). Cardiac output rose from 5.81 ± 0.69 to 6.72 ± 0.59 l/min. Calculated total peripheral resistance, heart rate and body weight were unchanged. No such changes were seen in patients with Addison's disease.3. The haemodynamic characteristics of ACTH in patients with mild untreated essential hypertension are similar to those in the experimental model of ACTH induced hypertension in sheep.