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  • 1
    Electronic Resource
    Electronic Resource
    Effect of impairment of renal function on the accumulation and disposition of isoxicam (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 585-588 
    Details
    ISSN: 1432-1041
    Keywords: isoxicam ; pharmacokinetics ; renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The accumulation and disposition of the non-steroidal antiinflammatory drug isoxicam were investigated following its oral administration to 6 subjects with normal renal function and 13 patients with diminished renal function. Isoxicam was given daily as a single oral dose for 14–15 consecutive days. Steady-state plasma levels were achieved after 13 days. The effect of differences in renal function on the kinetics of isoxicam appeared to be minimal. Accumulation of isoxicam was similar in both groups of subjects and there was no significant difference between the groups in the plasma clearance or terminal half-life of isoxicam. There were substantial differences between individuals in the apparent plasma clearance and half-life of the drug, and this is reflected in the 7-fold range of steady-state plasma isoxicam concentrations encountered in the subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544071
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Prevention of pre-eclampsia in high risk women with renal disease: A prospective randomized trial of heparin and dipyridamole (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 1 (1995), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Twenty-one women with primary glomerulonephritis and a history of a poor outcome in previous pregnancies were randomized to receive heparin, 15 000 units subcutaneously and dipyridamole, 400 mg daily (n= 10) or no treatment (n= 11) from 14 weeks of gestation. the women were well matched in terms of the type of underlying glomerulonephritis and previous pregnancy complications. the treated group showed a significantly lower incidence of hypertension (P〈0.03) and of overall maternal complication (P〈0.03). the days spent in hospital prior to delivery were 18 in the treated group and 27 in the control group (P〈0.01). In all other parameters which were measured the outcome was better in the treated group although these did not achieve statistical signficance. In the control group the pregnancy complications were similar to those in previous pregnancies but very few complications occurred in treated patients. Heparin and dipyridamole were used because of the activation of coagulation in preeclampsia and because of the prominence of fibrin in renal and uterine vessels in pre-eclampsia. As heparin suppresses both the action and the production of endothelin, the benefit of treatment could have reflected endothelin inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1995.tb00043.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    VASCULAR LESIONS AND ANGIOTENSIN IN MALIGNANT HYPERTENSION IN THE ABSENCE OF VASOPRESSIN (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1 Vasopressin deficient homozygous Brattleboro rats develop malignant renal hypertension following complete aortic-ligature between the renal arteries.3 The levels of PRA and AH in the malignant hypertensive Brattleboro rats were not different from those in Long-Evans rats with malignant hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00810.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Antibodies to polyclonal IgA, IgA1, and IgA2 and isotype-specific immune complexes in IgA nephropathy (1989)
    Springer
    Journal of clinical immunology 9 (1989), S. 306-312 
    Details
    ISSN: 1573-2592
    Keywords: Anti-IgA antibodies ; IgA nephropathy ; immune complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concentrations of serum IgG and IgM antibodies to polyclonal IgA (IgAp), IgA1, and IgA2 were determined by enzyme immunoassay in 31 patients with IgA nephropathy and 30 healthy controls. Patients with IgA nephropathy had significantly raised concentrations of serum IgA compared to controls (Mann-WhitneyU test,P=0.001) and increased concentrations of conglutinin-binding IgA immune complexes (P=0.024). No differences in the median concentrations of IgG and IgM anti-IgA antibodies were found between the patients and the controls. In serum samples from healthy controls there was a significant positive correlation between IgM anti-IgAp and IgA immune complex concentrations (P=0.05), which contrasted with the finding of an inverse correlation between IgM anti-IgAp and IgA immune complex concentrations in patients with IgA nephropathy (P〈0.05). In addition, the concentrations of conglutinin binding IgM immune complexes in serum were found to correlate with the concentration of IgM anti-IgAp (0.010〈P〈0.025), IgM anti-IgA1, and IgM anti-IgA2 (P«0.005 for both) in patients with IgA nephropathy but not in controls. IgM anti-IgA antibodies may be important in augmenting the clearance of IgA immune complexes from the serum of patients with IgA nephropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918662
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    Paper (German National Licenses)
    Fulltext
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