ISSN:
1432-1041
Schlagwort(e):
acrivastine
;
H1-antagonist
;
histamine bronchial challenge
;
onset of effect
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The onset of effect of acrivastine, a new H1-antagonist, has been assessed using antagonism of histamine-induced bronchoconstriction in sensitive volunteers. Acrivastine administered 30, 45, 60 or 90 min before challenge produced a right-shift of the histamine dose-response curve of at least 8-fold indicating that a clinically desired degree of H1-antagonism was present within 30 min of ingestion of the recommended therapeutic dose.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00315119