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Digitale Medien

Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man (1975)

Penttilä, O. ; Hurme, H. ; Neuvonen, P. J.

Springer

European journal of clinical pharmacology 9 (1975), S. 131-134

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Details

ISSN: 1432-1041

Schlagwort(e): Drug interaction ; drug absorption ; zinc sulphate ; tetracycline ; doxycycline

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary A possible interaction between zinc sulphate and tetracycline or doxycycline was examined in a cross-over study in seven volunteers. A single dose of zinc sulphate (45 mg Zn++) was given simultaneously with tetracycline hydrochloride (500 mg) or doxycycline chloride (200 mg). The serum concentration of tetracycline, the area under the serum tetracycline concentration-time curve and the excretion of tetracycline in urine were reduced by about 30% (p〈0.05) from the respective control values. The absorption of doxycycline was not influenced significantly by zinc sulphate. The clinical significance of the zinc-tetracycline interaction seems to be of limited importance.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00614009

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