ISSN:
1432-1041
Keywords:
Drug interaction
;
drug absorption
;
zinc sulphate
;
tetracycline
;
doxycycline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A possible interaction between zinc sulphate and tetracycline or doxycycline was examined in a cross-over study in seven volunteers. A single dose of zinc sulphate (45 mg Zn++) was given simultaneously with tetracycline hydrochloride (500 mg) or doxycycline chloride (200 mg). The serum concentration of tetracycline, the area under the serum tetracycline concentration-time curve and the excretion of tetracycline in urine were reduced by about 30% (p〈0.05) from the respective control values. The absorption of doxycycline was not influenced significantly by zinc sulphate. The clinical significance of the zinc-tetracycline interaction seems to be of limited importance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00614009
