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Digitale Medien

Abnormal platelet mitochondrial function in patients affected by migraine with and without aura (1994)

Sangiorgi, S ; Mochi, M ; Riva, R ; [weitere]

USA/Oxford, UK : Blackwell Science Ltd

Cephalalgia 14 (1994), S. 0

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Details

ISSN: 1468-2982

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: To investigate energy metabolism in migraine, we determined platelet mitochondrial enzyme activities in 40 patients with migraine with aura and in 40 patients with migraine without aura during attack-free intervals and in 24 healthy control subjects. NADH-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities in both patient groups were significantly lower than in controls (p 〈 0.01), while NADH-cytochrome-c-reductase activity was reduced only in migraine with aura (p 〈0.01). No alteration in succinate-dehydrogenase was observed. Monoamine-oxidase activity differed between sexes (p 〈 0.05) but within each sex group no difference was observed between patients and controls. We hypothesize that the defect in mitochondrial enzymes observed indicates a systemic impairment of mitochondrial function in migraine patients.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1468-2982.1994.1401021.x

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