ISSN:
1468-2982
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
To investigate energy metabolism in migraine, we determined platelet mitochondrial enzyme activities in 40 patients with migraine with aura and in 40 patients with migraine without aura during attack-free intervals and in 24 healthy control subjects. NADH-dehydrogenase, citrate synthase and cytochrome-c-oxidase activities in both patient groups were significantly lower than in controls (p 〈 0.01), while NADH-cytochrome-c-reductase activity was reduced only in migraine with aura (p 〈0.01). No alteration in succinate-dehydrogenase was observed. Monoamine-oxidase activity differed between sexes (p 〈 0.05) but within each sex group no difference was observed between patients and controls. We hypothesize that the defect in mitochondrial enzymes observed indicates a systemic impairment of mitochondrial function in migraine patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1468-2982.1994.1401021.x
