ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract CBA mice were treated before skin grafting with a course of either the methylhydrazine derivative Ro 4-6824 or cyclophosphamide, combined with donor type lymphoid cells. No further immunosuppressive treatment was applied after the grafting. Marked prolongation of graft survival and specific tolerance to (CBAxA)F1 and A skin homografts could be induced with Ro 4-6824, but not with cyclophosphamide. Tumors occurred in two tolerant mice after 10 months. Besides by administration of donor lymphoid cells, the effect of Ro 4-6824 pretreatment is also potentiated by heterologous antilymphocytic serum (ALS) and by thymectomy. The mice treated with Ro 4-6824 showed more profoud depletion of lymphoid tissue in the lymph nodes than after ALS. In addition, marked atrophy of the thymus occurred. In the spleen, Ro 4-6824 prevented the plasma cell response to ALS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01982396