ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Conclusion Due to the large number of parameters in this communication only one dose of histamine was investigated. This dose (6 μg/kg) was chosen because it caused short-acting but remarkable effects in the circulatory system and induced plasma histamine levels as high as found after administration of histamine releasers [8]. With this dose of histamine it could be shown that several effects of histamine in the circulatory system of dogs depended on the actual plasma histamine levels. H1- and H2-receptor antagonists applied separately from each other are able to block only few histamine effects in the circulatory system. They influence the circulatory reactions to histamine not only by acting on the receptors, but also by altering the actual plasma histamine levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01972666