ISSN:
1432-0428
Schlagwort(e):
Isolated perfused canine pancreas
;
VIP
;
GIP
;
caerulein
;
gastrin
;
secretin
;
glucagon
;
bombesin
;
acetyl choline
;
adrenaline
;
release of insulin
;
release of glucagon
;
release of PP
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The release of pancreatic polypeptide (PP) by gut hormones, acetyl choline and adrenaline was investigated in an isolated perfused pancreas preparation. PP was potently released by 1 nmol/l caerulein (186±12%, p〈0.001) and gastric inhibitory peptide (GIP) (211±31%, p〈0.005) as well as by 1 [νmol/l acetyl choline (1097±59%, p〈0.001). A significant two-fold release of PP was also evoked by 1 nmol/l vasoactive intestinal peptide (VIP) (129±38%, p〈0.02 and gastrin (108±25% p〈0.01). Insulin release, induced by high glucose concentration was enhanced by both GIP (210 ±38%, p〈(0.01) and VIP (48±5%, p〈0.001). In addition GIP enhanced the release of glucagon by 179±18% (p〈0.001) at 1.4 mmol/l glucose and by 127±24% (p〈0.005) at 8.3 mmol/l glucose. Thus no simple inter-relationship appears to exist between the control of the three circulating islet hormones.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01228136
